ID   A0A2W2B3G5_9BACT        Unreviewed;       259 AA.
AC   A0A2W2B3G5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   ORFNames=DN068_02940 {ECO:0000313|EMBL:PZF74548.1};
OS   Taibaiella soli.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Taibaiella.
OX   NCBI_TaxID=1649169 {ECO:0000313|EMBL:PZF74548.1, ECO:0000313|Proteomes:UP000248745};
RN   [1] {ECO:0000313|EMBL:PZF74548.1, ECO:0000313|Proteomes:UP000248745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R1-15 {ECO:0000313|EMBL:PZF74548.1,
RC   ECO:0000313|Proteomes:UP000248745};
RA   Kim M.-K., Park S., Kim T.-S., Joung Y., Han J.-H., Kim S.B.;
RT   "Mucibacter soli gen. nov., sp. nov., a new member of the family
RT   Chitinophagaceae producing mucin.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZF74548.1}.
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DR   EMBL; QKTW01000003; PZF74548.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2B3G5; -.
DR   OrthoDB; 9795084at2; -.
DR   Proteomes; UP000248745; Unassembled WGS sequence.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   NCBIfam; TIGR02772; Ku_bact; 1.
DR   PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01875}; Reference proteome {ECO:0000313|Proteomes:UP000248745}.
FT   DOMAIN          52..180
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
SQ   SEQUENCE   259 AA;  29426 MW;  406EBA0007299C84 CRC64;
     MRAIWTGTIG FGLVNIPIKI YTAIQSSTLD LDMLDKKNHA NIKFQRVNES TGRVVEWENI
     VKGYKYGDEY VVLEDADFEK ASPEKSKTID INEFVKEEEI DANFFDTPYY CEPAKGGERA
     YALLAAALKE TGKVALGTFV MRTKENFCML KAEGDLIEVI KLRFPEEIRA TTELTLPKQT
     EVKPAELKMA VSLITQLTPK KFNIDKYKDT YSAALMKIIE AKAKGKTVSQ PKFKMVQSKS
     KDLMDQLKES LETRKKVRV
//