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Database: UniProt
Entry: A0A2W2CJ41_9ACTN
LinkDB: A0A2W2CJ41_9ACTN
Original site: A0A2W2CJ41_9ACTN 
ID   A0A2W2CJ41_9ACTN        Unreviewed;       710 AA.
AC   A0A2W2CJ41;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE            EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN   ORFNames=C1I93_25295 {ECO:0000313|EMBL:PZF88157.1};
OS   Micromonospora endophytica.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=515350 {ECO:0000313|EMBL:PZF88157.1, ECO:0000313|Proteomes:UP000248627};
RN   [1] {ECO:0000313|EMBL:PZF88157.1, ECO:0000313|Proteomes:UP000248627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45430 {ECO:0000313|EMBL:PZF88157.1,
RC   ECO:0000313|Proteomes:UP000248627};
RA   Sahin N., Ay H., Saygin H.;
RT   "Draft genome sequence of Jishengella endophytica.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC         Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC         (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC         cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC         D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC         diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC         Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC         ChEBI:CHEBI:78435; EC=2.4.1.129;
CC         Evidence={ECO:0000256|ARBA:ARBA00023988};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZF88157.1}.
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DR   EMBL; POTX01000244; PZF88157.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2CJ41; -.
DR   OrthoDB; 3397599at2; -.
DR   Proteomes; UP000248627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001264; Glyco_trans_51.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR036950; PBP_transglycosylase.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR32282:SF33; PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE; 1.
DR   Pfam; PF00912; Transgly; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
PE   4: Predicted;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Transferase {ECO:0000313|EMBL:PZF88157.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          74..258
FT                   /note="Glycosyl transferase family 51"
FT                   /evidence="ECO:0000259|Pfam:PF00912"
FT   DOMAIN          363..667
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   710 AA;  76021 MW;  4C0B0E66CB1ECD04 CRC64;
     MSNRPLAAAG RLVPLLRAGL IAGLVVAAVA YPVVAVTGLG AKATAHAVES KTRLLTTALP
     AETSYLYAPD GKTVLTMFYE EYRQYTKITD ISPNMQQAIV AAEDNRFYQH HGVDPKGVAR
     AFVANARSSG VSQGASTLTM QYVRMALRDS ANSPKEVQEA TAQTPVRKVK EMRMAVDLEK
     ELSKEEILER YLNSAYFGHR AYGIYAASEI FFSKTPKDLT PVEAATLAGL VKSPSQFDPA
     SSDQKEATAR RNYVLDNMTR LGYLSPDSAA AAKTEPIRLK LSYPPNDCAG VPEKWNSWGF
     LCDYLKNWWS AQPAFGANRL ERMDKLRRGG YRIVLSMDPK IQAAAEKNVG TEGNTGSPFA
     NGIVVAEPGT GRVKAMAVNR TYSLDVNENP LSSNPEAGPN VRANYPNTVA PLMGGGDLPG
     YQAGSTFKMF PMLAALDAGM TLNTTFNAPH SYRSEVYDGW QPSNASGAMS GTQTMWSGFG
     KSVNTYFVWL EEQVGAERAV RLAEQLGLRW RTDVDREHAS PSKANKWGAF TLGVSDATPL
     EMANAYAAVA ADGRYCEAMP VSAIYNRDGT PATYTTAGGI AREVAKPRCR QVVSADAARA
     ATDAARCPTG DTPAKGGCGG WSTADSVRGT VGRPVAGKTG TTDSTRSAWF VGYTPELAAA
     SFISDPDNPF NAVGDGQSQI PIAAVANTLR DALKGKPVRD FAPPSDRIVG
//
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