ID A0A2W2CR59_9ACTN Unreviewed; 660 AA.
AC A0A2W2CR59;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=C1I99_24105 {ECO:0000313|EMBL:PZF90789.1};
OS Micromonospora deserti.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2070366 {ECO:0000313|EMBL:PZF90789.1, ECO:0000313|Proteomes:UP000248749};
RN [1] {ECO:0000313|EMBL:PZF90789.1, ECO:0000313|Proteomes:UP000248749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13K206 {ECO:0000313|EMBL:PZF90789.1,
RC ECO:0000313|Proteomes:UP000248749};
RA Sahin N., Saygin H., Ay H.;
RT "Draft genome sequence of Salinispora sp. 13K206.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZF90789.1}.
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DR EMBL; POUB01000222; PZF90789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W2CR59; -.
DR OrthoDB; 308915at2; -.
DR Proteomes; UP000248749; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06577; PASTA_pknB; 4.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; NF033483; PknB_PASTA_kin; 1.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR Pfam; PF03793; PASTA; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 4.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:PZF90789.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248749};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:PZF90789.1};
KW Transferase {ECO:0000313|EMBL:PZF90789.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..306
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 402..465
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 466..533
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 534..599
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 600..660
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 334..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 69976 MW; 90FE19CD20176E7C CRC64;
MDTQVADTLL GSLIDGRYRI RGRVARGGMA TVYTATDERL ERTVAVKIIH PTQAPEARAR
LAGFLERFTD EAKTIARLTH PNVVAVYDQG THAGLPYLVM EYVRGRTLRD VLAERRRLNP
DEALAIAEQM LAAIAAAHRA GLVHRDVKPE NVLVAEAPTG GAANLVDSVV KVADFGLARA
VEASADDEQG GQLMATVAYV APELVTEGRA DPRTDVYSAG IVLFEMLTGR VPYDGDRPVD
VAWQHVDRDV PAPSTLVPGL PKVLDDLVAR ATRRDPGARP TDAGALLAEV QVARDDLGSP
NTHTAVLRRV PDEPPVSQPT MVVAAVRPAE RPAWARLPSG GGQRAGRRRA PEEGVGARSR
LTALRTLLMG DPRGRMAVAA AVVVLGLVAA VGGWWFGVGR YTAAPQLVTL SKADAEAQAA
RAGFTLAYAD PRYDEKVPKD AVLAQVPVSA SRIVKGGTIT LTLSLGPERF PVPDVVGKEF
ELAEADLTNV KLEVAKGTAR YDDNLPAGVV VDTNPKPGTE VKPGDKVTVI LSKGRAPITV
PNLVGKNLAE ARTALAQLGL VAVETYKDSD KPKDEILGQS PADGAGLEKG AEVKLEVSKG
PPLVVVPRVV DLPCLQAKQL LESQGFPVAV QFNPNGTVRF QNPGENSQVP PGTQVTLGCL
//
