ID A0A2W2DB19_9ACTN Unreviewed; 413 AA.
AC A0A2W2DB19;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Zinc metalloprotease {ECO:0000313|EMBL:PZF89783.1};
GN ORFNames=C1I99_25145 {ECO:0000313|EMBL:PZF89783.1};
OS Micromonospora deserti.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2070366 {ECO:0000313|EMBL:PZF89783.1, ECO:0000313|Proteomes:UP000248749};
RN [1] {ECO:0000313|EMBL:PZF89783.1, ECO:0000313|Proteomes:UP000248749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13K206 {ECO:0000313|EMBL:PZF89783.1,
RC ECO:0000313|Proteomes:UP000248749};
RA Sahin N., Saygin H., Ay H.;
RT "Draft genome sequence of Salinispora sp. 13K206.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZF89783.1}.
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DR EMBL; POUB01000242; PZF89783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W2DB19; -.
DR OrthoDB; 9782003at2; -.
DR Proteomes; UP000248749; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00989; PDZ_metalloprotease; 1.
DR CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR004387; Pept_M50_Zn.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:PZF89783.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:PZF89783.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248749};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..208
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
SQ SEQUENCE 413 AA; 44221 MW; 49284DAE0EA564D9 CRC64;
MLYLLGVVVI ALGILISVSL HEAGHMLTAK AFGMKVTRYF VGFGPTIFSF RRGETEYGLK
AIPLGGFCKI VGMTPQDDDV DPADEHRAMW RYPVWKRTIV MSAGSVTHFA LAVIAIWLAA
MFMGLPNRDL PNPLPAHVAV QECVIPAAEV RECAPGDPVS PAKQAGLRDD DEILAVNGAP
VADYTALVKA IRDLSPGQTA TIRYERDGVQ GEVQAQLAAV QRPPLTDPEA APVTVAALGV
AGPKLPPGVP ANVTYGPIEA IPATADYTGS LAVGTYEAMK RIPEKVPALW EAVTGGERDK
DTPISVVGAS RLGGEALEHG VWQLLVILFI SLNFFVGVFN LLPLLPLDGG HIAIAWFERA
RSWIYARLGR ADPGRVDYLK LMPLTYAVIL VGGAFTLLTA TADIVNPITL FSR
//
