ID   A0A2W2DW40_9ACTN        Unreviewed;       816 AA.
AC   A0A2W2DW40;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Sarcosine dehydrogenase {ECO:0000313|EMBL:PZG14401.1};
GN   ORFNames=C1J01_27035 {ECO:0000313|EMBL:PZG14401.1};
OS   Nonomuraea aridisoli.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2070368 {ECO:0000313|EMBL:PZG14401.1, ECO:0000313|Proteomes:UP000249304};
RN   [1] {ECO:0000313|EMBL:PZG14401.1, ECO:0000313|Proteomes:UP000249304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KC333 {ECO:0000313|EMBL:PZG14401.1,
RC   ECO:0000313|Proteomes:UP000249304};
RA   Sahin N., Saygin H., Ay H.;
RT   "Draft genome sequence of Nonomuraea sp. KC333.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZG14401.1}.
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DR   EMBL; POUD01000129; PZG14401.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2DW40; -.
DR   OrthoDB; 2055370at2; -.
DR   Proteomes; UP000249304; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000249304}.
FT   DOMAIN          5..359
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          363..418
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          421..712
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          732..808
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   816 AA;  89042 MW;  E30B84F715537764 CRC64;
     MSRPRVVIVG AGIVGCALAD ELTERGWTDV TVVDQGPLFA AGGSSSHAPG LVFQTNPSKT
     MTAFAAYTVA KYAALGPSCF RQVGGLEVAT TPERWADLHR KLGWAESWGV EARLLDAGEC
     ARLWPLLDQG KVLGGFHVPS DGLAAAVACG EAQAARATER GARFLAGHMV VGVEQRGGRV
     IGVSVVTPAG HRTIPADVVV CAAGFWGPSI GRMAGLTVPL QPLAHQYARS GPLPPRPQGP
     ILRHQDRDLY FRQHGDRIGI GSYAHRPMPV AQDEIGPKGT TMPSVQAFTE EDFEPSWRDA
     VELLPALAET KYADGINGVF SFTPDGFPLI GEAPHLDGFW LAEAVWVTHS AGVARALAEV
     LVDGRSGFDL HECELGRFEQ AQLSPAFVEE RGRQNFVEVY DVIHPLQPME SPRPLRTSPF
     HVRQRELGAY FLEAAGWERP HWFESNVPLL EDLVRRRRDE YADVPEEARG AAAEPFLGVM
     QRDAWASRHW SPIAAAESWA TRERVALYDM TPLKRIEVGG PGAAAFLQRM TTNNVDKKPG
     SVTYTLMLDA AGGIRSDLTV ARLDEETFQV GANGNLDLEW LTRHAPGGVR VRDLTPGTCC
     VGVWGPWARG LVEDLTDMDM SHEGFPYFTC KSGYVGHVPV LAMRVSYVGE LGWELYTTAD
     MGLKLWDTLW SPGLAVAGGR AAFNSLRLEK GYRLWGVDMT TEHNPYEAGL AFAVRQDKDF
     LGRDALSADV TRKLVPLVAT EVVMGKEPVR HQGRTVGHVT SAAYGHTIHR PVAYAWLPIE
     LAEPGTHVDI SYFGRRVPAE VAAEPLYDPG MEKIRR
//