ID   A0A2W2E6L0_9ACTN        Unreviewed;       739 AA.
AC   A0A2W2E6L0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:PZG12845.1};
GN   ORFNames=C1J01_31635 {ECO:0000313|EMBL:PZG12845.1};
OS   Nonomuraea aridisoli.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2070368 {ECO:0000313|EMBL:PZG12845.1, ECO:0000313|Proteomes:UP000249304};
RN   [1] {ECO:0000313|EMBL:PZG12845.1, ECO:0000313|Proteomes:UP000249304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KC333 {ECO:0000313|EMBL:PZG12845.1,
RC   ECO:0000313|Proteomes:UP000249304};
RA   Sahin N., Saygin H., Ay H.;
RT   "Draft genome sequence of Nonomuraea sp. KC333.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZG12845.1}.
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DR   EMBL; POUD01000174; PZG12845.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2E6L0; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000249304; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 3.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249304};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        180..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        304..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        519..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        550..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        595..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        641..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        674..697
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          204..329
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          719..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  76647 MW;  32C6E83DC7B2F3B4 CRC64;
     MTRLLGRLGG WCARHGWIVL VTWVLAAAAL MGSNLAFPSP TSSDASIPGT DAQRAHDLMK
     TGFGSGYEAG GTVQLLVYSA DGPLLEETRK EAVEDAVDRL RTMPHVAEVE TPFRMGGISS
     NLQIGLIGVR LEGHDPDAIG TITQDLSKAA DPAREAGLEV VPADNSNPAG KEIKTGPSEV
     VGVICALVVL VFAFGTLVAA TVPIFVALVS VASGLGLIGL LGWVVDMPKQ AGIMATMVGL
     GVGIDYALFL LSRHRRLLAD GVPVVESVRR TVASSGGAVV FAGGTVIIAL SALLLAGFPL
     LATLGWVTGI SVVAAVLTSV TLVPALLGLL GHRVNALRVP FLRGSGAGGA GWAGLGAWVA
     RRPWRVLLGA VVVLGALAAP ALALKLGPID EGYGAQGSES RRAYELMATG FGPGSNGPLI
     VVAELPEKVD DADDPLVEDL AREVKAVDGV AHVGDPKVNT SGRSVLLQAV PEYAPSDERT
     AQVVRDVRAI ELPGVRVHVG GEVAGLTDAG DRLAERTPLV IAVVVLLSAL LLLLAFRAPL
     VAVKAAVMNL VSLGAAFGAL ALVFSLGLGT GLVGMDPPVS SSYLAPLFFS VPIESYVPLM
     LFAVLFGLSM DYEVFLLTAV RQSYLRHGRN ARAVAEGLGS TGRVITSAAL IMVAVFTAFI
     AYPDSLVKTF GVGLAVAIAV DATIIRGFLV PATMVLLGRA NWWCPRWLDR ILPNLSVEGH
     EEDGSAPEPR RPEPVKAGV
//