ID A0A2W2ENS0_9ACTN Unreviewed; 353 AA.
AC A0A2W2ENS0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:PZG24381.1};
GN ORFNames=C1I95_00205 {ECO:0000313|EMBL:PZG24381.1};
OS Micromonospora craterilacus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1655439 {ECO:0000313|EMBL:PZG24381.1, ECO:0000313|Proteomes:UP000248924};
RN [1] {ECO:0000313|EMBL:PZG24381.1, ECO:0000313|Proteomes:UP000248924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA12 {ECO:0000313|EMBL:PZG24381.1,
RC ECO:0000313|Proteomes:UP000248924};
RA Sahin N., Ay H., Saygin H.;
RT "Draft genome sequence of Jishengella sp. NA12.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZG24381.1}.
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DR EMBL; POTY01000001; PZG24381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W2ENS0; -.
DR OrthoDB; 3804952at2; -.
DR Proteomes; UP000248924; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:PZG24381.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248924};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:PZG24381.1}.
FT DOMAIN 16..78
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 116..327
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 252
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 353 AA; 37675 MW; F142E48240FA0652 CRC64;
MATTTTTAQP GLRHRMQQLI YGFFTAQTLH VAVRLRIPDL LAEGKPDLAE LAEATGAHAP
SLRRLLRALV YLEVLAEPEP GRFVLTEQGE VLRSDVTGSM RELVLLLSGP ESWAAWGQLE
HSVRTGGVAW DHVHGQSCFA YLMADPQRQA AFNAAMAEGS RAFVPTLLSA YDFAELDTVV
DVGGGSGALL AGVLVAHPHL RGTVFDTPDG VADAARTLAE QGVADRCEVR AGDFFESVPP
GADAYLLKSV LHDWDDEQCV AVLGTVRRAA RADSRVLLVE SLMPTTVGTG PSVAQVVMND
LNMMVCHGGR ERTVAEFREL LRAAGFRLES VTPCPAPSVM GILEAAPVAG AES
//
