ID   A0A2W2H201_9ACTN        Unreviewed;       834 AA.
AC   A0A2W2H201;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=C1I98_28895 {ECO:0000313|EMBL:PZG33054.1};
OS   Spongiactinospora gelatinilytica.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Spongiactinospora.
OX   NCBI_TaxID=2666298 {ECO:0000313|EMBL:PZG33054.1, ECO:0000313|Proteomes:UP000248544};
RN   [1] {ECO:0000313|EMBL:PZG33054.1, ECO:0000313|Proteomes:UP000248544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7K107 {ECO:0000313|EMBL:PZG33054.1,
RC   ECO:0000313|Proteomes:UP000248544};
RA   Sahin N., Saygin H., Ay H.;
RT   "Draft genome sequence of Sphaerisporangium sp. 7K107.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZG33054.1}.
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DR   EMBL; POUA01000299; PZG33054.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2H201; -.
DR   Proteomes; UP000248544; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PZG33054.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          20..473
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          776..796
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          812..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  89490 MW;  7B292D69456875AD CRC64;
     MARRTTTPPP EDFEERIIDI DVSSEMRTSY LEYAYSVIYQ RALPDARDGL KPVQRRILYS
     MNEMGLRPDR GHVKSSRVVG DVMGKLHPHG DTAIYDALVR MAQPFSMRLA LIDGHGNFGS
     PDDAPAAMRY TEARLATAAT MLVQSIDEDT VDFKPNYDGQ ETEPTVLPSA LPNLLVNGAA
     GIAVGMATNM APHNLVEVIS AARHLIKHPD AGLDALMRFV PGPDLPTGGT IIGLDGVRDA
     YQTGRGTFKM RAKCAIDQVT PRRKGIVVTE LPFNVGPERV VTKIRELVTA KRLQGISDLK
     DLTDRHKGLR LVIEIKNGFN PEAVLEDLYR LTPMEETFGI NNVALVDGQP RTLGLRELLQ
     VYVDHRIDVV RRRSAYRRRK REERLHLVDG LVIALLNIDE VIQVIRSSDD SGQARARLME
     VFELSEIQAA YILDTPLRRL TRFDKLELDR ERQTLQEEIA QLSEILSSDT RLRAVVSKEL
     AEVSKQFGTP RRTVLLESSG AAGTVAVPLE VADDPCRVLL SSTGLLARTA DATPLATEGE
     RSNHDVLVSA VASTVRGEIG VVTSHGRMIR VSVVDLPTLP SVAAPPTLSG GHPVSEYVTL
     VPGETVVGIG SLTAGGAGLA LGTAGGVVKR VAPDYPANRD EFEVIGLKDD DRVVGAVELP
     SEDHDLVFIA SNAQLLRFPA SAVRPQGRPA GGMAGMRLDE GAKVIFFGAV DPALPARVVT
     IAGSATALPG TQTGGGKVSD YAEFPAKGRA TGGVRAQRFL KGEDTLLLAW AGPAPAKGAS
     TTGKPVPLPE ELGRRDGSGI RITNAVAAIG GGLGTHPITG SPTTAAQDDS DDPF
//