ID   A0A2W2L3G6_9ACTN        Unreviewed;       155 AA.
AC   A0A2W2L3G6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=VapC toxin family PIN domain ribonuclease {ECO:0000313|EMBL:PZG96055.1};
GN   ORFNames=C1I97_26610 {ECO:0000313|EMBL:PZG96055.1};
OS   Streptomyces sp. NTH33.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1735453 {ECO:0000313|EMBL:PZG96055.1, ECO:0000313|Proteomes:UP000248559};
RN   [1] {ECO:0000313|EMBL:PZG96055.1, ECO:0000313|Proteomes:UP000248559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NTH33 {ECO:0000313|EMBL:PZG96055.1,
RC   ECO:0000313|Proteomes:UP000248559};
RA   Sahin N., Ay H., Saygin H.;
RT   "Draft genome sequence of Streptomyces sp. NTH33.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000256|ARBA:ARBA00038093}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZG96055.1}.
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DR   EMBL; POTZ01000344; PZG96055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2L3G6; -.
DR   OrthoDB; 3257696at2; -.
DR   Proteomes; UP000248559; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd18732; PIN_MtVapC4-C5_like; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   PANTHER; PTHR33653; RIBONUCLEASE VAPC2; 1.
DR   PANTHER; PTHR33653:SF1; RIBONUCLEASE VAPC2; 1.
DR   Pfam; PF01850; PIN; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248559};
KW   Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT   DOMAIN          22..138
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|Pfam:PF01850"
SQ   SEQUENCE   155 AA;  17269 MW;  5CE1ECB5DBE5F809 CRC64;
     MPADRPTYAQ GLLDTDIMIL RRWVAPEELP DEMAITAITL AELSAGPHEV RRNDEQSGYD
     EHAERARRLD VLQRAENEFD PLPFDAEAAR IYGRICAAVI SAGRKPRRRV ADLMIAAIAV
     AEDLPLFTTN PDDFKGLDDL LTVVPVTRPK VPHEG
//