ID   A0A2W2M0E5_9ACTN        Unreviewed;       442 AA.
AC   A0A2W2M0E5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:PZH16172.1};
GN   ORFNames=C1I97_07040 {ECO:0000313|EMBL:PZH16172.1};
OS   Streptomyces sp. NTH33.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1735453 {ECO:0000313|EMBL:PZH16172.1, ECO:0000313|Proteomes:UP000248559};
RN   [1] {ECO:0000313|EMBL:PZH16172.1, ECO:0000313|Proteomes:UP000248559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NTH33 {ECO:0000313|EMBL:PZH16172.1,
RC   ECO:0000313|Proteomes:UP000248559};
RA   Sahin N., Ay H., Saygin H.;
RT   "Draft genome sequence of Streptomyces sp. NTH33.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZH16172.1}.
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DR   EMBL; POTZ01000044; PZH16172.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2M0E5; -.
DR   OrthoDB; 9793589at2; -.
DR   Proteomes; UP000248559; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248559};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          14..397
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          404..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  45151 MW;  8479147256462CD6 CRC64;
     MSHLVATVLG GVALVVLASW LLGGLARRLG QPTVVGQILA GVALGPTLLG RLPGDPSGYL
     FPAEARPFLA MLAQIAVVLF MFVAGYETDF RTFKAGRTAV SVAAAALLVP MALAVAVVEL
     CSGLFAAVDP AHADQSSFAM FMAVAVSITA LPVLAAIVRE RGAAGTRAGT VAIAAAGFMD
     VAAWLVLAAV LSDAGQATRW SWPAALALLT AFAGFLFGVA RPSLRWWLER PATLMSNPVP
     VALVLALGSA WVTESLGFHA VFGGFLAGLA MPRRDGAPDA DVLKPMEQTS GMLLPLFFAT
     TGLSVDIGTL GADGFGLLGV ILLVAIVGKA VPAYGVARLR GLDARQSALV AVMVNTRGLT
     ELIVLDVGRS AGLIGEELYA VLVLMALATT FTTGPLLQLI GRGAQDGRPA TRKGHSDHST
     SSSAHPVQTV GTGGEKAGGN AT
//