ID   A0A2W2M3A5_9ACTN        Unreviewed;       332 AA.
AC   A0A2W2M3A5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=NADP-dependent oxidoreductase {ECO:0000313|EMBL:PZH13140.1};
GN   ORFNames=C1I97_11695 {ECO:0000313|EMBL:PZH13140.1};
OS   Streptomyces sp. NTH33.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1735453 {ECO:0000313|EMBL:PZH13140.1, ECO:0000313|Proteomes:UP000248559};
RN   [1] {ECO:0000313|EMBL:PZH13140.1, ECO:0000313|Proteomes:UP000248559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NTH33 {ECO:0000313|EMBL:PZH13140.1,
RC   ECO:0000313|Proteomes:UP000248559};
RA   Sahin N., Ay H., Saygin H.;
RT   "Draft genome sequence of Streptomyces sp. NTH33.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZH13140.1}.
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DR   EMBL; POTZ01000087; PZH13140.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W2M3A5; -.
DR   OrthoDB; 9805663at2; -.
DR   Proteomes; UP000248559; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248559}.
FT   DOMAIN          14..330
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   332 AA;  35662 MW;  C4D26A444FA9ECD2 CRC64;
     MINREWHLIG RPVGRPKPED FALVETEAPQ PREGQVLVRN EYLSVDPYMR GRMSAAKSYV
     APYELGKAMQ GGAVGEVVAS NAEGVAVGDH VLHFGGWREY AAVDARHAVR VDPEAAPLSA
     YLGVLGMTGL TAYAGLLRTA SFKEGDIVFV SGAAGAVGSQ VGQLARLKGA ARVIGSAGSD
     EKVKLLLEEY GFDAAFNYRN GPVSEQLRAA APDGIDVYFD NVGGDHLEAA IGSLNQGGRI
     AVCGMISVYN NTEPAPGPRN LARLIQTRGR IEGFLVGDHY DLQPQFVREV GPWVRDGRLK
     YRETVVEGIE NTLEAFLGVL RGDNIGKMLV KL
//