ID A0A2W2NV77_9ACTN Unreviewed; 1173 AA.
AC A0A2W2NV77;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=C1I97_01270 {ECO:0000313|EMBL:PZH20308.1};
OS Streptomyces sp. NTH33.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1735453 {ECO:0000313|EMBL:PZH20308.1, ECO:0000313|Proteomes:UP000248559};
RN [1] {ECO:0000313|EMBL:PZH20308.1, ECO:0000313|Proteomes:UP000248559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NTH33 {ECO:0000313|EMBL:PZH20308.1,
RC ECO:0000313|Proteomes:UP000248559};
RA Sahin N., Ay H., Saygin H.;
RT "Draft genome sequence of Streptomyces sp. NTH33.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZH20308.1}.
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DR EMBL; POTZ01000006; PZH20308.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W2NV77; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000248559; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248559}.
FT DOMAIN 13..88
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1077..1152
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1053..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 127957 MW; 47FE385EA70D3C9C CRC64;
MTLQTGAEPN DGRPVASVVD VVSATWAAVL RTGTPEPDAN FFALGGNSLQ GARVISRLRE
ELGVQIPLYV LFEHQTVGEL AAAVEALGTP ASAAAPTIEP LEQRADGVFH APTSFVQQRM
WVEEHIQGPS SRYSIPSAIE IEGPLDVEAL EEAVRSLVER HEVFRTTIRA VDGVPQQVVA
PDSDVALHTV DLRPEPADQR EQILLDRLAA SARRPFDIER GPLLRVELYR LDEDWHVLLI
NLHHIITDVR SFELAVSELL RLYSRKSDPS AGARQPSVQY ADYAAWQRRT IGDAAVDDQL
EYWKEQLRAP LPVLDLPTDM PYRDTSSGRG ASVTVELPRA VSRRLRELSR EHDSTPFMTL
LALLNVLMHR YSGQSDIVIG TPSANRDLPE LEGMLGCFLN TLAIRSDLSG DPTLTELLHR
VRETALAAYA HQDVPYERVV NAVTVDRSAR QGLFRVMLAF QHEIPVPDLP GITVSDVDLG
LEAVKFDLVF AVTETEFTYR VSLEYDSDLF VEDTAWRILD HLGVLAADAV AAPGKRVSEL
TVLPEEERRR IAKWSASAHG PYATDLFLHR LFEEQARRTP DAPAVESGTD VLTYRELDAL
ADRLAAELAG RGIGTDDLVG LCAEPSLELM VGILGIIKAG AGYVPLDPIA PADRMAYVVA
DSGMKVLVAT PALREQLPAE VVAGVDVTTV DAKAPGQHGA VPDTRRQPPV EVDSSQLVYL
MYTSGTTGRP KGVGLPHRAI TPWIQWAQDI RPIGPGVRVV HNLFYHFDWS VEQMFHALTS
GACLVMLPGE LRADPAATAR FIDERAINML YLTPTQMRGI ADTGISMPSL RHVSMGGENL
DAELVARTRK VVSGDCEIWN EYGPTETAGA ALVGRMGDEP LERTSMPLGE LIANATCSVV
DRWENPQPIG VPGELWIGGD GVARGYRNLP GLTAERFTAD PSNPGRRLYR TGDLVRWLPN
GEMEFLGRVD SQVKIRGVRV ELEEIESVLR AHPDVANAVA VLEPDQRLVA YLESAPGASP
DEGSVRAHLA PKLPIVMQPS VFVWLESIPS SATGKVDRSR LPRPAAAPAP AQPAAVPPST
AMEHLVAAVW TEVLRQDVRS VEADFFEIGG DSFSLLSVVN ALRKELALDI PVRAVVDSPT
VAGLAAYLES LRWALRSQVS AVDTGGEREV GEL
//
