ID   A0A2W5WQ05_9MICO        Unreviewed;       384 AA.
AC   A0A2W5WQ05;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha {ECO:0000313|EMBL:PZR53427.1};
GN   Name=pdhA {ECO:0000313|EMBL:PZR53427.1};
GN   ORFNames=DNL40_07930 {ECO:0000313|EMBL:PZR53427.1};
OS   Xylanimonas oleitrophica.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC   Promicromonosporaceae; Xylanimonas.
OX   NCBI_TaxID=2607479 {ECO:0000313|EMBL:PZR53427.1, ECO:0000313|Proteomes:UP000248783};
RN   [1] {ECO:0000313|EMBL:PZR53427.1, ECO:0000313|Proteomes:UP000248783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PW21 {ECO:0000313|EMBL:PZR53427.1,
RC   ECO:0000313|Proteomes:UP000248783};
RA   Nagkirti P., Shaikh A., Gowdaman V., Engineer A.E., Dagar S.,
RA   Dhakephalkar P.K.;
RT   "Whole genome sequencing of a novel hydrocarbon degrading bacterial strain,
RT   PW21 isolated from oil contaminated produced water sample.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZR53427.1}.
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DR   EMBL; QKWH01000004; PZR53427.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W5WQ05; -.
DR   Proteomes; UP000248783; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR017596; PdhA/BkdA.
DR   InterPro; IPR029061; THDP-binding.
DR   NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR   PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:PZR53427.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248783}.
FT   DOMAIN          55..333
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   384 AA;  41984 MW;  2F2579E21982A302 CRC64;
     MKTDATGGPD AATQDVTPLV QLVAPDGSRT ADPEHAAYRE RVAHLAPADL RAMYRDMVLT
     RRFDDESTAL QRQGELALFA QGRGQEAAQV GSAHALAPQD HVFPSYREHG VLHVRGVDPV
     DRLRLFRGED HGGWDPAEHN VQLYTLVIGS HALHAAGYAM GVQRDGLVGT GDAARDTAVV
     TYFGDGATAQ GDVSEALVFA AVNNAPLVLF CQNNQWAISE PTSRQARGPL YRRGEGFGVP
     GVRVDGNDVL ACYAVMADAL ERARSGGGPT FVEAYTYRMG AHTTSDDPTR YRERAEEDYW
     RRRDPIDRLA ALLRSEGEWD EEWAADVEAE AEALGERLRT EVRALGAPPT TAMFDHVYAT
     PHATVDEERA WLAEYESDLT EGAR
//