ID A0A2W6MS88_9HELI Unreviewed; 939 AA.
AC A0A2W6MS88;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=B6S12_09130 {ECO:0000313|EMBL:PZT47424.1};
OS Helicobacter valdiviensis.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1458358 {ECO:0000313|EMBL:PZT47424.1, ECO:0000313|Proteomes:UP000249746};
RN [1] {ECO:0000313|EMBL:PZT47424.1, ECO:0000313|Proteomes:UP000249746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WBE14 {ECO:0000313|EMBL:PZT47424.1,
RC ECO:0000313|Proteomes:UP000249746};
RA Fresia P., Jara R., Sierra R., Ferres I., Greif G., Iraola G., Collado L.;
RT "Genomic and clinical evidence uncovers the enterohepatic species
RT Helicobacter valdiviensis as a potential human intestinal pathogen.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZT47424.1}.
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DR EMBL; NBIU01000035; PZT47424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W6MS88; -.
DR Proteomes; UP000249746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000249746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 599..931
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 939 AA; 105032 MW; AD1F1E01654D202F CRC64;
MNPSPLDHII ITNAKENNLK NIHLNIPKNK LVVLTGLSGS GKSTLAFDTL YAEGQRRYIE
SLSSYARQFL DKIGKPDVDK IEGLTPAIAI DQKTTSKNPR STVGTITEIY DYLRLLYARV
GTQHCHLCGK PISKMNASDI IEQVQKLEEG KKILILAPLV KEKKGTFSDK LESLRQKGYI
RAQINGVLVR LDEEINLAKT KKHTIKVVID RLVVNPQNNT RIAEAIEKAL KESYGEVEIE
LLNEEGKNDL IHFSEHLACF DCKVSFSPLE PLSFSFNSPK GACAKCDGLG IRYSIDTKKV
IDSSLPLVEG GIKIFYGFNK SYYNELFKGV CKTFKINPKS TFDELEEHEQ KLLLYGNQEE
VEFTWKNSPL KRPWSGIIAI AYDMFKDNKD LADYMSEKVC EECKGHRLLP QSLAVKVASK
TLGDILDFSI ADCYGFFANE QNFTYFNEQQ ALIASPILKE ICERLYFLYD VGLGYLSLGR
DARSISGGES QRIRIASQIG SGLTGVMYVL DEPSIGLHER DTLKLIKTLR SLQQKGNSVI
VVEHDKETIE HADFIVDIGP GAGKYGGEVV FSGNLTQLLA SNTQTAQYLS GAKKIEYFIR
RNQQEWITLK NVNINNIHNL SVEIPLQNFV CVTGVSGSGK SSLILQTLLP VAQELLNNRK
KVKKVDGVEI LGLEKLDKVI YLDQSPIGRT PRSNPATYTG AMDEIRQVFS QTKEAQIRNY
SVSRFSFNVK GGRCEKCQGD GEIKIEMHFL PDILVKCDSC HGMRYNPQTL EVEYKGKNIA
QVLEMSVDEA CEFFSKIPKI YQKLRTLKDV GLGYITLGQN AITLSGGEAQ RIKLAKELSR
KDTGRTLYVL DEPTTGLHFA DVDKLTKVLH HLTDLGNSVI VIEHNLDMIK NADYIIDVGP
EGGSKGGNIV DSGTPEHIVK RHKKTGSYTG KFLEKELQR
//
