ID A0A2W7J1U8_9PROT Unreviewed; 1706 AA.
AC A0A2W7J1U8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Alpha-2-macroglobulin family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=C8P66_113110 {ECO:0000313|EMBL:PZW44943.1};
OS Humitalea rosea.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Humitalea.
OX NCBI_TaxID=990373 {ECO:0000313|EMBL:PZW44943.1, ECO:0000313|Proteomes:UP000249688};
RN [1] {ECO:0000313|EMBL:PZW44943.1, ECO:0000313|Proteomes:UP000249688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24525 {ECO:0000313|EMBL:PZW44943.1,
RC ECO:0000313|Proteomes:UP000249688};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZW44943.1}.
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DR EMBL; QKYU01000013; PZW44943.1; -; Genomic_DNA.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000249688; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000249688};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1706
FT /note="Alpha-2-macroglobulin family protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015919195"
FT DOMAIN 857..998
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1058..1147
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1706 AA; 180678 MW; 02544378CC785450 CRC64;
MPRLLALLMF LLAVPASAQM LNFEPQGVQR DGAAYEAQLS RRFPAGGTPA QRTAAEARAT
AAERSGKWDQ AVQAWEERIG AGNPTAETWL ALSRAQLERT PPEAARALQA AWQSFMLVPS
GPPEIPSLRM MAQALARQGQ LGEALAATAA AQSRDPENPA LRRELADARQ AAGMLFTRAR
VEAEAEPARA CLAFTVPPRR GDDWQPQDWA RAEPPLPGMA VERDGDQICV TGLPYGRATR
VVLRAGLPGE GGVNLRTETT VAVSVPNRRP RIAFDNRSYL LPRGQAPRIA VATINVSSLD
IRVMRVGERG LVPLRRDWKP GDEMEGWTAM RLSEESAPTI WSGRAEVPRF QANQSQNTIL
PLPEAVRTAG PGLYVVWVKA GDGQDQGVSG AALPLVITDL GLTAWRSSQG LAVQARSFAE
AMPRAGVQVT LMSRGNEILA SAETGADGVA RFAAALLRGQ GPLAPISVHA ATADDLAALD
LEAASFDLSD RGASGLPHPG ALDAFLWLDR GIYRPGETVQ TMALLRDASG VPQELPIRLR
LRRPNGQIAE EFVPSRQEGG AFAWPIRLSR SAQVGVWTVE ALADPDAPPI GRTTFRVDAF
VPETLAIEAG PLPPAITLGR PVTVPLSARF LYGAPAAGLS GRAELRLRQA PEQWPAWRGW
HIGLIEDPFD PGLGSADIAP LNEQGRGEVG FTIDSMPDTS RPVALEVAVS LSDPGGRESR
TSFSLPVIGT TPFLAIRPAF KDDAVDDGAE AAFDIAALSP AGEATAAALK LRLVRERPDW
RMVVSDGQAR WQTVWRDEAV DTADLQTTPG QPARFARSLG FGRYRIEVTR PGTLAIASYR
FRAGWATSEN AEVPDKVDVA ADQASYAPGA SARIRITPPF AGHASVAVLT DRLVSVQEVE
VPVGGAEVSV PVDAAWGPGA YVAVTVFRAG TAAAGAPARA LGLAWVGLDP ATRTLAVAIE
GEPMVRPRTR VTIPVRLTGA TGAARLTLAA VDEGILRITR FPTPDPVRHF TGRRVLGVDI
RDDYGRLIAP PDGEATVLRQ GGDGFEGDLS VQPPQRVVAL FSGIVTPGPD GVAMVPLDLP
DFAGELRLMA VAWDGTRIGA AARPLTVRDQ VVAEALLPRF LAPGDEARLP LLVHNLDLPS
GEIIVTLATE GPLALQGPAR FATMLATGER ARPVTTLAAT GAGEAVLRLT VTGPQGFSAT
RESRITIRSA RPWASSVATS TLAPGTEARI EPPLARFVPG TTRATVTFGG ILRYDAAALL
RAVVDYSFGC TEQTASRIMA LATAPPALAP ENREAALTQA ITALFDRQRY DGMLGLWSSG
GEAEDWVSAY AAETLLRAKA EGAVLPEAAM GALLSALEER SERAPDDPSS RANQAYRLHV
LAMAGRHRLG AARRLMEQLD DLPTPLSRAQ LGSAFALGGD TPRAELAFAA ALASPARQYW
HQDYGSPARD AIAVAVLLRE SGVLAARLSD AIGRLPGADF TPERSSTQEQ AWAVLASRVL
NAGGRPVQVS VGGRSLPVGL SAMAPLTGPL TGPVAVRNLG DAPVLQSISV TGLPAQPLPA
ARAGMRITRR FFTPNGEALN LDALKQTQSF VLLLEATSET GDTHNALIQQ GLPAGFEIIG
RLPAGEVPGM DFLGELSSVE AEPALDDRYA AAVVLSPDSR VARVAVRLRA VTAGRFELPG
AEVADMYRPA VFARQNTGRL TIAPQD
//
