ID A0A2W7PBG4_9BACT Unreviewed; 873 AA.
AC A0A2W7PBG4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=LX69_00093 {ECO:0000313|EMBL:PZX20672.1};
OS Breznakibacter xylanolyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC Breznakibacter.
OX NCBI_TaxID=990 {ECO:0000313|EMBL:PZX20672.1, ECO:0000313|Proteomes:UP000249239};
RN [1] {ECO:0000313|EMBL:PZX20672.1, ECO:0000313|Proteomes:UP000249239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6779 {ECO:0000313|EMBL:PZX20672.1,
RC ECO:0000313|Proteomes:UP000249239};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZX20672.1}.
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DR EMBL; QKZK01000001; PZX20672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W7PBG4; -.
DR Proteomes; UP000249239; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000249239}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 873 AA; 98009 MW; B3DA7115AB65AC57 CRC64;
MSQAKPGVVE TPLMKQYYQI KEKYPDAILL FRVGDFYETF SDDAIKASEI LGITLTRRAN
GSASFVELAG FPHHALDTYL PKLVRAGQRV AVCDQLEDPK MTKTIVKRGV TELVTPGVAI
NDNILEHREN NFLASVHLEK NMAGVAFVDY STGEFLVAEG SFEYVEKLLS GFKPKEVLFE
KTKRAQFEEH FGSKLYTYGM DDWAFAPDSA RDRLLKHFET KSLKGFGIHS FTAAVVAAGA
AMHYLDLTQH HQLGHITTLS RIEEDKYVWL DKFTIRNLEL FGSSNEGARS LIDVIDKTVS
PMGSRLLKRW IALPLKDVKQ INDRLDTVEY FFRQPDVREL VEEELRVIGD LERLVSKVAA
GRLTPREMVQ VKKALFCIEP IKQACMASGN ESLMNIGEQL NFCATIRDRI ERELDNDPPA
AIVKGGVIRQ GVSPELDELR GLAFSGKDYL ASLQDRLSEE SGIPSLKINF NNVFGYYIEV
RNTHKDKVPD TWIRKQTLVN AERYITQELK VYEEKILGAE EKILALETRL FNDLLASLTD
YISVIQVDAA LLARLDCLVG FNRLAIENKY VRPVVSDDEE LTIKAGRHPV IEKQLPPGEA
YVPNDVHLNT SDQQVIIITG PNMAGKSALL RQTALIVLLA QAGCYVPAES AHIGLVDKIF
TRVGASDNIS QGESTFMVEM NEASSILNNL SSRSLVLFDE LGRGTSTYDG ISIAWSIVEY
IHESVKGKAK TLFATHYHEL NEMEKSFPRI KNYNVSVKEV DNHVIFLRKL VKGGSNHSFG
IHVARMAGMP KSVVKRADAI LKELENTHRK GQLSKPTADI AQHREGMQLS FFQLDDPVLK
QIRDEISSLD INQLTPIEAL NKLNDIKRLI GLK
//
