ID   A0A2W7SD63_9BACT        Unreviewed;       665 AA.
AC   A0A2W7SD63;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=2-oxoisovalerate dehydrogenase E1 component {ECO:0000313|EMBL:PZX60805.1};
GN   ORFNames=LX80_02289 {ECO:0000313|EMBL:PZX60805.1};
OS   Hydrotalea sandarakina.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Hydrotalea.
OX   NCBI_TaxID=1004304 {ECO:0000313|EMBL:PZX60805.1, ECO:0000313|Proteomes:UP000249720};
RN   [1] {ECO:0000313|EMBL:PZX60805.1, ECO:0000313|Proteomes:UP000249720}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23241 {ECO:0000313|EMBL:PZX60805.1,
RC   ECO:0000313|Proteomes:UP000249720};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PZX60805.1}.
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DR   EMBL; QKZV01000008; PZX60805.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2W7SD63; -.
DR   OrthoDB; 9771835at2; -.
DR   Proteomes; UP000249720; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249720}.
FT   DOMAIN          348..521
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   665 AA;  74467 MW;  D7980D324F9BCF51 CRC64;
     MQFNRKALTN AQLINFYHEL LYPRLIEEKM LVLLRQGKIS KWFSGIGQEA IAVGATLALE
     SDEWIMPLHR NLGVFTSRKM PLHKLFMQWQ GNHEGYSKGR ERSFHFGSKE HFICGMISHL
     GPQLAVADGA GLANQLQQKH KVALAFTGDG GTSEGDFHEA LNVAAVWNLP VIFIIENNGY
     GLSTPVNEQY RCKNLVDKAI GYGMEGVQID GNNILEVYDT ISGVRKYCIE QQKPYLIECM
     TFRMRGHEEA SGTKYVPKEL FDIWAEKDPI KNYEEYLLNE QILTPSAIED IRHNMKLAIE
     EELQIAYQAA PMVANTREEL ADVYAPAPPV EEPSENMRNN SATTEKPHRL IDALKDGLDL
     AMQKHDKLIL MGQDIAEYGG AFKITEGLLE KYGKNRVRNT PLCESAIIGT ALGLSLEGFK
     SMVEMQFADF VSVGFNQIVN NLAKIHYRWN QNADVVVRMP TGAGVGAGPF HSQSNEAWFT
     HVPGLKVVYP ATPFDAKGLL LASFNDPNPI LFFEHKALYR SVTGYVPNEY YEIPIGKARV
     AQSGSDLSII TYGAGVHWAL QYCAEHTDSS IEIIDLRTLL PLDYDSIRNT VLKTGKVLVL
     HEDTLTGGIG AEISAWITEH CFEHLDAPVM RCASLDTPVP FNTTLEQNFL AHARLAETIE
     RLLNY
//