ID A0A2X0K1N1_9ACTN Unreviewed; 2064 AA.
AC A0A2X0K1N1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:RAG83175.1};
GN ORFNames=DN069_23590 {ECO:0000313|EMBL:RAG83175.1};
OS Streptacidiphilus pinicola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptacidiphilus.
OX NCBI_TaxID=2219663 {ECO:0000313|EMBL:RAG83175.1, ECO:0000313|Proteomes:UP000248889};
RN [1] {ECO:0000313|EMBL:RAG83175.1, ECO:0000313|Proteomes:UP000248889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS16-CNU450 {ECO:0000313|EMBL:RAG83175.1,
RC ECO:0000313|Proteomes:UP000248889};
RA Roh S.G., Park S., Kim M.-K., Yun B.-R., Park J., Kim M.J., Kim Y.S.,
RA Kim S.B.;
RT "Streptacidiphilus pinicola sp. nov., isolated from pine grove soil.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAG83175.1}.
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DR EMBL; QKYN01000093; RAG83175.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000248889; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248889}.
FT DOMAIN 977..1051
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1992..2064
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2064 AA; 220144 MW; BF5E1150A0284D6D CRC64;
MTPSRLEAAL PLTPLQHGML FHALYENEGV DAYTVQVAFE WCGPLGSDAL RGALERLVAR
HAVLRAGFQT RKSGEPVQLI SRSVELPWQE LDLRGLDGPE QRRRLARYRE DERARRFDLA
RPPLLRAAAV RLDDDRQVLV LTYHHILLDS WSFQLVLQEL FALCAAPAGD GLPPVVPFRR
YLAWLEAQDR DAAGEAWRAA FAGFEEPTLV AAGRGGDAGP QRLPRLTSVD LSEELTDALV
RSARRAGLTV NTLVQGAWAL LLAGLTGRQD VVFGQTVSGR PPQLEGVEEI VGLLIGAAPV
RVSMDPNETV TALLRRIQRE QMDLEPHHHL GLSEIQRRVG LGDLYDSTVA FASGPSGVGA
AHDDVRVGDT AVRVLPDSPG EGGAATGSTH YPLNLTAAVG RSLRLALSHQ EDVFDTLDAD
RLLGRLSTLL TVFAMEPDTL VGRIPLLAED ELEKVLRKWN DTEQRLPEEL TLPDLFRAQV
ARTPAATALV CAGQELSYAE LDARVQELAA VLRARGVGAG DRVAVAVHRS VELVVALHAV
LATGATYLPV DPDYPTERIG WIVEDARPAL VVTTGRDAGA LPEGPPRLLL DEPLPGVDRS
PARRATLPGD AAYLLFTSGS TGRPKGVVVS HRAIVNSLAW MQHRFGLRPD DRVLLKTSAG
FDTSLWELVW TLQTGAALVI AEPGGHKDAA YLADLIDRER VTTVQFVPSM LQAFLLEELT
GRCRSLRRVF CIGEALPPQT RDRFRAAGFD AELHNLYGPT EAAVQITVAD ELMAQGVDAP
VTIGRPIWNS QAYVLDGALR PVPPGVAGEL YLGGSQLADG YTNRPALTAE RFVADPYGEP
GSRMYRTGDV VRWTEEGELD YLGRADDQVK LRGQRIELGE IQTALTRHPA VGHAVVVVRD
GLGGARQLVG YVVAAPGAVL SRDELLAHAS ATLPSYMLPQ TLVELAELPL TPNGKLDRKA
LPAPLAAPEA GGRPVSGPAE TTLARLFAAV LHGEEADGIG AEDSFFELGG DSITSIQLVA
RARQAGLRFT PKDVFTHRTV AALARVAQTD APPVAEPAES GSGTLPATPV MHWLADHHGP
VEDFAQATLL TVPAGLGRGR LVSAVQALLD RHDALRLRAR RQGRAQAVGG EPWALDVSPA
GTVRAWDCVR RVPAEGLDAE ALTALLAVET ARARAELAPE LRQVLRVVWL DAGPAQGRLL
LVAHHLAVDE VSWRILVPDL RAAWEAAEAG GGPHAPAPVA TSLRTWARRL TEAASRPERV
TELPFWEGLL AGGDAPLTPR PLDPERDVHG TARSRSWTLP PEQAQALLGA LPTAYRATVE
EVLLTGLALA VERGRDGEAG ADGAPAAPGL LVDLEGHGRQ QDHGTDLDLD LSGTVGWFTD
LRPVRIDPGV GVDGTPVTPG TALKRVKEQV RALPDHGIGY GLLRRLNPRT APVLAALPTP
QVGFNYLGRS GRTASALWAS APEGAELGPM AHPEMSLAHA WEVTAVAADT ADGPALCLQL
MWPEGLFTEE QAERLGSAWL GALRELAEHA GAPGAGGLTP ADVLPAVVGQ RELEGFEAAV
ARHGGRLADA LPVTPMQEGL LFHHRYRPEA PDVYHVQLVL ELGGAVEPAA LRAACQRLVD
RHAALRASFR TGASGAPLQL VAERVQVPWQ ELTVDEAGAA AFLSADRLRR FDVTEAPLLR
FALLREGTGR ARLVLTVHHV LVDGWSLPLL LNELNDLLGG AEVSVGTPVP VRPYYAWLAA
QDRTAARAAW SAALAGLDGP TLVAPGVDAA GLPTLPERVS TELPEGVTRD LGRLARAADT
TTNTVVQAAY AALVGELTGR RDVVVGATVS VRPPELPGVE AMVGLLLATV PVRVRLEATE
SLTTLLRRLH REQGELAAHA HLGAAEIARA AGLGPLHDAS MVFENYPQEQ REQPEQGGRP
RVTGIDGVDA YHYPLKLTAA PGERLLLALD HRPEAIPAPV ARRLLARLVD LLTAFAAAPA
DGSVGALLDV ADRDPDRAAE LAVLAGEVLG RAVGPGEDLF AAGLDSVGAL RLAGRIGLRY
GEAPDVHRVF ACRTAAGLAA ALHG
//
