ID   A0A2X0KED4_9ACTN        Unreviewed;      1054 AA.
AC   A0A2X0KED4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:RAG85519.1};
GN   ORFNames=DN069_11330 {ECO:0000313|EMBL:RAG85519.1};
OS   Streptacidiphilus pinicola.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptacidiphilus.
OX   NCBI_TaxID=2219663 {ECO:0000313|EMBL:RAG85519.1, ECO:0000313|Proteomes:UP000248889};
RN   [1] {ECO:0000313|EMBL:RAG85519.1, ECO:0000313|Proteomes:UP000248889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMS16-CNU450 {ECO:0000313|EMBL:RAG85519.1,
RC   ECO:0000313|Proteomes:UP000248889};
RA   Roh S.G., Park S., Kim M.-K., Yun B.-R., Park J., Kim M.J., Kim Y.S.,
RA   Kim S.B.;
RT   "Streptacidiphilus pinicola sp. nov., isolated from pine grove soil.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RAG85519.1}.
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DR   EMBL; QKYN01000040; RAG85519.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2X0KED4; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000248889; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248889}.
FT   DOMAIN          519..597
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1054 AA;  114968 MW;  DBD42258EF7C0985 CRC64;
     MHDDRRIIET RIRKLLDRVI RPALHSHPRP LTLSAWQVEG EPVPVAEALT ADYQPFALGS
     SWGGPWSTTW LRARARIPEE WAGRRVEAVF DLGFDLSRGP GGQAEGLIHD ANGSPMQGLH
     PYHRSVLLSC SATAGEDVEL LVELAANPWI VGSAGRNTHY GSRETAGTEH LYRLGQAEIA
     VREEEVWQLI HDVEVLDELM HELPEHSTRR HEILHALRRA ADAVDPGDVP GTAAAARARL
     AQVLAQPAHA SAHTVAAVGH AHIDSAWLWP VRETVRKCAR TFTNITTLAQ EYPELVFACS
     SAQQYAWMKE QHPEVFARIR KAVAAGTWAP VGGMWVEADG NLPGGEALAR QLVYGRRFFT
     EEFGIDQPGV WLPDSFGYTA AYPQLARLAG ARWFLTQKLS WNETNRLPHH TFAWEGIDGS
     RVFTHFPPVD SYNAELTGAE LAHAERNFAE KGVASRSLAP FGHGDGGGGP TPSMLEKARR
     LRDLEGSPRV VVESPDAFFA AAAAEHERLP VWRGELYLEN HRGTYTSQAR TKRGNRRAEA
     LLREAELWAA TAAVRAGAAY PYERLERLWQ RVLLNQFHDI LPGSSIAWVH QQAEREYGEI
     HGELEEIVAD AVAQLPGGPG FLNSGPLPRR EVAFLHPGQA VAGGQLLADG RTAVLAETPA
     LGSGTASIPA SPVTARAQDG GYVLDNGRLR VVVDHRGLVT SAYDHAADRE AVAPGTAGNL
     LQIHPDDPNL WSAWNLDSYY RDTVRDLDHA ESVTLVDEGP LLASVRVERA HGASRLIQHL
     ELAAESGWLT VRNEVDWQER DTVLKAAWPI DVHAEHESAE IQFGHVRRPT HENTSWDAAR
     FELWAHRWIH VGEHGWGAVL LTDSTYGHDL RRDTRADGGT TTTVRLSLLR APHSPDPQAD
     RGHHRFSYAF APGAGVGQAV AGGYALSLPL RPAAVAAAPL VALDNDAVVV ESVKLADDRS
     GDVVVRLYEA GGGTALARLT AGFPLAAAWD CDLLEQPWPQ PAPGTPGAAE PRPAVLPDGA
     DALRLRLRPF QILTLRLRPA QPEGAEAADG GEPG
//