ID A0A2X0LMB5_9BASI Unreviewed; 2363 AA.
AC A0A2X0LMB5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 22-FEB-2023, entry version 16.
DE SubName: Full=BZ3500_MvSof-1268-A1-R1_Chr1-2g01414 protein {ECO:0000313|EMBL:SCZ91446.1};
GN ORFNames=BZ3500_MVSOF-1268-A1-R1_CHR1-2G01414
GN {ECO:0000313|EMBL:SCZ91446.1};
OS Microbotryum saponariae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=289078 {ECO:0000313|EMBL:SCZ91446.1, ECO:0000313|Proteomes:UP000249723};
RN [1] {ECO:0000313|Proteomes:UP000249723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jeantristanb JTB J.-T., Ricardo R.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FMWP01000015; SCZ91446.1; -; Genomic_DNA.
DR STRING; 289078.A0A2X0LMB5; -.
DR Proteomes; UP000249723; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00821; PH; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000249723}.
FT DOMAIN 1305..1483
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1911..1962
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 2006..2197
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 28..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1829..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2204..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2287..2315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2230..2249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2291..2306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2363 AA; 253871 MW; 6406E065D253F79B CRC64;
MLGRKKKRQG SISSVEAFSA TGITAGHAGV GHVSTASSSS SNATTAPGPP PASWSVRAND
HLNAGMTPTA APASSSSTSG GGGSRAFNYF VERARGAVGF GSRERTKSNS SDDTSTFASI
STSEPGSTSS HTISSGFNPT AKAPSSTSSA SHNPKSSSSL DINSVPLGAA PMSIPYSVSM
HEIAPHQSRG AASYGATSTM ATTSSSVGAS ATSNSASFFS RRTPTASNPH APAWLAPTSA
SDSRGGASYK LSTSPSSPNL STPILALSQE QLPAGRRRQG TSSSTGTSAD GGSPLLTSSR
STFARSNEDI SSRRQSRMWT AEDAPPVPML ARKSTEDFSS SRDTLGVEPT RRVRTTSLAP
NAALNSYPSS SNLSTSAPSS RGSRSPSLSP RLGPSDSPVP LPSSSSALNL SRQAAGSYSS
TNTLASNTTA ATSTHVSRSP ELGDRRRDSQ TIHCQGFLQR KADYVPMPSP SRLSPSGTAP
TISSPVATGS GSSQSYFSPR APSPRLRPTR LGAEVDLQKG WKPYRAILKG SKLYLHKPPA
DLSSTAKSMF PTTVLDPPSQ EPSPRTPAGF EGDASKRRQR AYWGAGGSAH PRLMVADESA
TSSSKHKVTG GTVEAITHEI IFATTFPVDE GSPARVGASE SAYDTFLDTL LLFQPYLSGP
PGLFATELQR FAALATRTSQ ESETATPASK AALEARLAKL IGDACLKYPQ DLSAMIESSA
EWRATMDEIL KQVHTLSSEE SNPKADELQK LWDQTIEKAS SSPPPLTAST EWASPSAASS
APRSGPASLP NSPTKARKRT PESPTPPSPT PDAVMQLTPH SLVQLDPVAF AAQIHAFHLD
RLTAINSDPL STSRLILRQA ASGDAPKWPS LLDIFSFSAS TPHSLTRVVV NSILAPLTPT
AAGPSSVIYM RAAVISQWVA IGEELRRRGD ATGWAAVAMG VCCRAVARLD EASRSVGAER
IELVRHTWAP ILRSINFSDD DESKISPLSF EPSEKGTAIP YLGSILEKAA AGLKASAAQI
PEQPDATLLL PLYDLREELG KVDSVWSREP PSAMQVALDP RLQHFLQRNS RLAHPEKPQL
SAYLASSLKA EPRLVAQGIN LLAKPRSAQE PSPLVPLVMV EPLPHISLVD RGQILASSRN
PALRHKGSYS NMSSNASDSV HPGGTQLARR ASYPPHAASA SLGLGAFARL RKDMTDPANT
LLPFADGDIV FTIVSNAVRT VPSTPTLVQN ERGTLSRTSS WIESRSSRGA GGPNRNSARQ
SLTPTLAPLS RVSSRGGSPV TVSPQLNEHS PTGPKLQAAS EEEPVHVVVR AGTVEAFVDL
LVLGISNLRT PSTDADGQSS LTGRRPLQLD AQDFRSAFFS TFRSFTTPLV LLDMLRKRYL
AAPNASLDHV NLTSERPFPA WSMAPISPGI EVDWAHIASI RVSVLRNISY WMDHHIGDFL
DDDELFTSAT TFLHFIESSE RANARPENAQ VLAELQKLLK RIGIDMLRPA VKSRAPVVMA
SATPLSYDEL DASQLVDRLD QIACRLTQNL SETDLLRYIE QLEIRVQADP ALWYPSCSIK
TDEEELVIAD SYSLLEAAQN DGAPLRQMPL SLHEVIRAHG VIRKWVLAHL TEPEISLRLR
TLRMVKALEM IEISRSRMAN VVFGGSVEDQ VSVVDPSLAG FVERVVISAV VAPESRLFAS
AWQGVASTRN VVSTDSLLAL VRHDLVVTDS TATLDPAWLN ERLVEIVSQV DSLSDGVSIN
FSKRRWIFNI IRNALVIRPS QPAYGSDDPL ISIERKIAGW GAWSMRTLRD AASGEGSKST
RSLKPFSRLV AAQQDKVRRE RTAKELVLKT QKTEQQQRAA REKEVAKAMD KSVSMRTRRM
TALFRGGGSR PSSVNTAASP ASTPSIPPPP SPQALRVLKD WMPSSKPYLV LPLSGVEVQP
YENGQRSFVF ELVTEDGQRS LFQASTAHEL RSWLDHFRRC GTEIAFRRAT FLAQTALAEE
PEEPAAAKSA TSTAAVKIPA SALFGTPLWE VLQREDSTIP RFMDSALATI TERGLLEVGI
YRISGENRVI QQLRQSLDRG GDPVSLLSKT DVHNVSGLLK LFLREMPEPL IPYDLYEPFI
TANAIEDYDE RLYAIRDLVW RLPQPNFHLL RRLSEHLDKV TDHEEVNSMH AANLSIIFAP
TLLKPTPGPT AFGLSMTNLG KAANIIKSII LQQNWIFGEE VVEEEQEHTP SMQASRELGT
EAASPPAFRS GYSANDSPQQ PTGLGLYDSS SPNARDVFGA AEDGMPTSSS THFLSGHSMA
EQNLAEEGRS INDISARERG KTNETETSQG DGEAQYAVIP ASSSSYLGDT LKLDFEFEHT
VVPPSPHGPV SAATAAQAGR HVE
//
