ID A0A2X0NLJ0_9BASI Unreviewed; 2012 AA.
AC A0A2X0NLJ0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=BQ5605_C011g06504 {ECO:0000313|EMBL:SGY12429.1};
GN ORFNames=BQ5605_C011G06504 {ECO:0000313|EMBL:SGY12429.1};
OS Microbotryum silenes-dioicae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=796604 {ECO:0000313|EMBL:SGY12429.1, ECO:0000313|Proteomes:UP000249464};
RN [1] {ECO:0000313|EMBL:SGY12429.1, ECO:0000313|Proteomes:UP000249464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; FQNC01000011; SGY12429.1; -; Genomic_DNA.
DR Proteomes; UP000249464; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09272; RNase_HI_RT_Ty1; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR013103; RVT_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF07727; RVT_2; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000249464};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Transposition {ECO:0000256|ARBA:ARBA00022578}.
FT DOMAIN 594..779
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1136..1295
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1448..1498
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2012 AA; 224907 MW; FDBEBCC3FB6D85B2 CRC64;
MPTPTAPSHS PTYKPNDPPQ LHSTLMEALR EYFMRLDFYN RRIARTPITS DYDKIEGAGM
GLQVFALKTW FTQGLSKHLA KPYAQFKSEL ICRAVPADFV WTQLAELHRL RQAPGHNIDA
FQEFSDQMRS LQMEIGFQVV SDQEVAKLVL LGTDPELCRI LRTHMVSSLA GWSDLSLEKL
ALDAPVVPTS PEAAEVFSDA HTDQPLEFDY QVFERIGREE WSVIAQRRQA IATQVGALQQ
RPTYSRPAAA SAAPHVATAA TGHSPITGGP RPVARLTVDE RAYLDQNHGC YRCRTLNADH
ISRNCPRYLS PMGASATPST PTSTAPAPRP GPRMVAAIRT FQETGDSTVF AGLSSDSEDD
NDPSYAPHPF PPLPVSLAGV HGTLLASALV DSGSPQTFLS EELVQRLGLE RRALEQHSKY
TLAMQNQVPT VFTCTHFVRV PLELANGLWA AGPTYAEVAP LGKDLAIILG GNFIYRHKME
LGLFPQPHLT CKANPIHAID LLVLSSQPCA AARVAAIAPV SDDEEQLRLA ALDHRLRAEF
ADRFPADIPP VHLYQSPVRH RIELDTPSTV VNLRGYPLPK KYREAWYLLL QEHLAAGRLR
PSRSAYSSPS FIIPKKGCDV DPTIAPRWVN DYRELNKHTI KDRTPLPLPD DILSTCSNAQ
FWAKIDMTNS FFQTKMAEED IHKTAVSTPW GLYEWTVMPM GLCNAPATHQ RCVNEALQGL
LGTICFVYLD DITIFADTLE EHEARVCQVL DALRRAELYC SPTKTNLATA ECSFLGHIIN
RAGVHTDPKK IQRIEYWSLP KTVKELRGFL GLVQYLRKFI PGLAEHTAAL TPLTRQGLSS
IATLWTPNEV RHFKAIKAIV TSLDCLRPPD HSANAAPFWV MTDASNQGIG GVLLQGQEWK
VARPIAYWSR QYIPAERNYP THEQELLAIV EALKEWRIDL LGGHFHILTD HSTLEHFQTQ
RTVLSRRQAR WLDTLAEFDY DLRYLPGEDN IVADAMSRYS FTDPLPTLVA AVSHVKLSDA
VKQQILDAYK TDPFCQQAMS NIGSVTSDFK IVDALLYLRG RLIIPSLAPL RESILHDAHD
AQGHLGDMKT YRTVQQAYFW PNMSRDVKHY VQQCDSCQRT KACTTRIAGK LHSLPVPMRP
MADIAINFIG PLPANKGFDR VLTITDRLLG YIRLLPAREA DTAAEVAARF HEGWHRLFGL
PQSIVSDRDK LFTSKFWTAL HKRLNIKLQL SSAFHPETDG RSEKTNKTAF QILRALVNKE
QSNWAECLAV CEYAINSSLN VATGKTPFEL VLGYTPSLAP LARVDGDDDL PSVEELLALR
FQACEDARDQ LAISKVRQAA QSNKKRQDKP FWAVGDLVLL DSSDRQKRLH TRKRRAAKLM
DCFDGPYRIV KAQPEISSHT LQLNGDDAAV PFFHTGKLKT CRKNDTALFP NREPARLGPV
DVGGEPEYII EDIVDERIRA GKQQYLVSWL SWPSDSNSWE PAEALEDTEA LDRWERRNEE
AISCLSHNLS VVRDPANWGD VIRSGQQDTW GGPAHDKFNS LLNKYEVFEV IDSCELPRHG
DIIDRKARLV AHGCAQRPGI DFEQNYAPVV KFMSIRALIA LVAANGYHVH QANVNKAYLH
GKLDKPLYMR VPQGIDRPGK ILRLSKSIYR LCQAGTIWNA EIDSTLRSLG YVPTQLDICI
YRCKHNGHSH YIALYVDDLL LVGPSTAEID RVLDALELAY GIKCLGPAEY ILGIQVKHGH
NGSITLSQER YLRDILARFQ FADAKPAGVP MQPGVVLNFE NSSATPEDCT RYLQAIGSLM
YAVVGTRPDL AFVVSYLARF SQQPGPEHWT AIKHVLRYIK GTLDLGLTYR KTNQPLHGYS
DANWGACLTT SRSTMDYAFI LSGAAIAWCS KREHRVAKST TDAEYLSLSY ASGDTIHLSE
LLSELGAPVP GPIVLYGDNQ GSLALAQHPT NHQGSRHTRI SEHYVRERVA EKEIEVRYIA
TGDMFANIFT KALGPKPFIF HRTNLGLRGA VV
//
