ID   A0A2X0NRA0_9BASI        Unreviewed;       662 AA.
AC   A0A2X0NRA0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Phosphoribosylaminoimidazole carboxylase {ECO:0000256|ARBA:ARBA00021059};
DE            EC=4.1.1.21 {ECO:0000256|ARBA:ARBA00012329};
GN   Name=BQ5605_C014g07446 {ECO:0000313|EMBL:SGY18699.1};
GN   ORFNames=BQ5605_C014G07446 {ECO:0000313|EMBL:SGY18699.1};
OS   Microbotryum silenes-dioicae.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX   NCBI_TaxID=796604 {ECO:0000313|EMBL:SGY18699.1, ECO:0000313|Proteomes:UP000249464};
RN   [1] {ECO:0000313|EMBL:SGY18699.1, ECO:0000313|Proteomes:UP000249464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004747}.
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DR   EMBL; FQNC01000016; SGY18699.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2X0NRA0; -.
DR   STRING; 796604.A0A2X0NRA0; -.
DR   UniPathway; UPA00074; UER00130.
DR   Proteomes; UP000249464; Unassembled WGS sequence.
DR   GO; GO:0043727; F:5-amino-4-imidazole carboxylate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   HAMAP; MF_01929; PurE_classI; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR003135; ATP-grasp_carboxylate-amine.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR033747; PurE_ClassI.
DR   InterPro; IPR000031; PurE_dom.
DR   InterPro; IPR040686; PurK_C.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   NCBIfam; TIGR01162; purE; 1.
DR   PANTHER; PTHR11609:SF5; PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE; 1.
DR   PANTHER; PTHR11609; PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7; 1.
DR   Pfam; PF00731; AIRC; 1.
DR   Pfam; PF02222; ATP-grasp; 2.
DR   Pfam; PF17769; PurK_C; 1.
DR   SMART; SM01001; AIRC; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52255; N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE); 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249464}.
FT   DOMAIN          124..384
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
FT   REGION          36..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  70305 MW;  92CCAC5C865995C2 CRC64;
     MLLQAASPLS IPIIVLDPEE GAPAKQVSAP ERLPLSQLAS TSSQAGSGPG PLSHLNGPFT
     SESHIRQLAQ NVDILTIEIE HVDVAALERV QHDFASTGGR SGEGVRIYPA PAVIRTIQDK
     YTQKLYLQER GIAVAPFLPI TGTGAAAADS VDPRADLRDS VRDAAKDFGY PLMLKSRHLA
     YDGKGNFVLR SENDIELALE ALIPDSSLTI QGARAPTDRL YAEKWAAFVQ EVAVMVVRGA
     DGSTRSYPAV ETVHRDSICH IVYAPLRPLC DGDYGVGSKQ KGAFSISAKP VDERAQELAV
     RAIDALGEGA VGVFGVEMFW LSDGPFLLVD FGDSCAIACQ ADLTSMSTGR LLLNEIAPRP
     HNSGHYTIEA CSISQYTAHL YAILSLPLPP IQFLPRSSAM LNLLGLSASA QSDFMGPSGV
     VRKAIELGAA VHLYGKAGCR KGRKMGHVTI VGESDEIVRS QLEQLVELLP GEYAEKAQRQ
     EATRSARSPL VSIVMGSDSD LPIMLNASSV LRQFEIPFEL SIVSAHRTPG RMVEFARTAA
     SRGIRVIIAG AGGAAHLPGM IASETILPVI GVPVKGSSLD GVDSLYSIVQ MPRGIPVAAM
     AINNSMNAGL LAVRILAAGG MGRLNTALAE YAAGLEDEVL AKVQTLENIG WDAYATIKLA
     KK
//