ID A0A2X0PQ12_9BASI Unreviewed; 1902 AA.
AC A0A2X0PQ12;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Actin cytoskeleton-regulatory complex protein PAN1 {ECO:0000256|ARBA:ARBA00015110};
DE AltName: Full=Actin cytoskeleton-regulatory complex protein pan1 {ECO:0000256|ARBA:ARBA00020728};
GN Name=BQ5605_C042g12048 {ECO:0000313|EMBL:SGZ31933.1};
GN ORFNames=BQ5605_C042G12048 {ECO:0000313|EMBL:SGZ31933.1};
OS Microbotryum silenes-dioicae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=796604 {ECO:0000313|EMBL:SGZ31933.1, ECO:0000313|Proteomes:UP000249464};
RN [1] {ECO:0000313|EMBL:SGZ31933.1, ECO:0000313|Proteomes:UP000249464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FQNC01000116; SGZ31933.1; -; Genomic_DNA.
DR STRING; 796604.A0A2X0PQ12; -.
DR Proteomes; UP000249464; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR013182; DUF1720.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF08226; DUF1720; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00027; EH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000249464};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 204..293
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 237..272
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1018..1035
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1218..1277
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1581..1759
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1793..1890
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 638..681
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 709..761
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..586
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..893
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1002
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1072
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1902 AA; 207995 MW; 5C2C46FC7FB05672 CRC64;
MSWLNQPYAG GYPGQQPQPG YLQSQPTGYM GQPMQQQPLQ GQRTGYAPQG GFQVSRVWPG
VRAGPTGFIG QRPPMQQMQV QPTGYAPSML QPQPTGYPAP MQQRPMATGY PFQQQQPPPP
QQQQPLMSQP TGMPGMGGGM QSQFLSTFMP APSLQPTSFI DPSQMQFAHS GHNGASLAQT
FQQRNQAQTG HADVPIPWAL TKDEKKRYDQ IFRAWDQQGT GFIEGRVSKE VFGQAGLDQN
DLMSIWNLAD VQDRGKLNID EFHVAMGLIY RRLNGNPIPQ TLPPEMAPPS ARDLDDSVGF
LTNLLKNDNN QRSTNQDFDG GRGSMAKARS LHDTAPRRDR KDATVFRNDD DEARAVYKSS
ARHLNRDQIR SRSETDSPSS DLDDIRNRLR TTRSTLDRSR DQDDEDEDLK DQLRNMKRRI
QRVQDDIDHN LGSGRRTTAK EDERRKLERE LLRLEYEELP ELERRIKEKE RDKKRDQRKY
ALERDSRNND SDRYGDRDRY STRKDPYESR SSSRRESPER GYNRGTYDNG DGREKRSRDR
DDDHYTSPSR GITSPSRART EPPPPPPAPG SERATPPPPP PAPVAALKSP AVDTRSMTPT
ERQAHIRAQA QARIQERLRA LGVAAPASGE NAVDTSVADR LEKDKAEAAA KAAKADEDLK
AKELERQAKL EREKLRGVAI EQSINSQNEA AVEQVREEVN AAAPESMIAK AANEQLDVEE
DALARREAQL KREKEERMAR IKQLEQEAHE AEENYARSKA MFAPKIAKVA PPPPAPRARP
AAPPFRTAPA PASATKPAVD DDETAPPAPR AADPAPAVIS SFLSPPVARS DVGAVGASPS
SESKNPFYRL QQGGASPAAT SAAPAASPSG KPNPFFASSS PPAGPPAPSA PLLAPVSPAQ
TALRQPGLVV KPEYRSPPVD DDDWDAKEKD VDESDSDDEI GGLRAAQANL AAKLFQGLGL
GPARPASAQG NTPTRSTAAS PDLGAPAAPP GPPAPSAPAA SPTPKAAPAF VVPTEAPPRS
ALLGAIQGGL TLRKTETKDK SGPAVTGSVI DDPSPPVRTH RAPSPPPAFA GPAAQVAPAA
NGGGSFGESH YNANRQSIAW LGSMAAVEGS SQNAQTFSNI ATVAEDEEPA EEAKSSTLPA
IVAASNEDDP LAPFDMTTTH RMKSLFAFQG EGPNDLSFKE NLVLNVHPSK DPAGDWLYGT
VESSGEQGWV PKSYVEAFTP QSAKALYAYD AASEEEMSFL EKDIISIVDS ADASWWQAEN
NGLIKLVPAS YIELGSPISF SPRLYTPYRI RLPSRTSEAH LASALASPRL ETAMTRPHDK
DQRLPMPSEN SRIFKVSGSR VADDSDSEIE TPDGGDPKER EAERLRVLEA AGLLVRGGPS
ADRRKRRQAP ARPPTKPTTG SVSGGGEGNE ILAEESVNAD SAPEEDVDQE GRVKDAYDIY
QRVMRELPPV PTTTSNRLSM VSDSTTPSTT AGSMLYPTSP PASPAPSSST VASSLATGAS
IKDQWQATTS GLRAKLGRPR ESSSAALDHA RLHISGPIIG EATGSAQSKS QESATPSNFG
ASWASMIDSG ALEIMPDRER KRQESMFELI TTEQAYVQSL QLTIEVFFNR LQPVIPAKAL
QVIFANIEDI LLFDTIFLSE LEDRQRTARL YIDTIGDIVK KHVRGYECYR GYCVNQANAA
RTLADLKRSD PQLRSFLEGS RIKGLELEHF LLEPMQRVTR LPLLLRQILR YTEQDHSDRA
LLTQSLEIAE GILGVINEAV RAHENEERLV YLSDVIEFSH SIEARLDLTA PTRLMGLRRL
LKEDRVTKAR SGRKLNVYLF NDLLIFTETK AGGNEVVYRW PIALEECIIR DQSRDDLTFA
VAHRGDTINV RTSSARQCLL WTQEIEQARK ACLAAVQKRR GM
//
