ID A0A2X0WTL7_9GAMM Unreviewed; 343 AA.
AC A0A2X0WTL7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|PIRNR:PIRNR005096};
GN Name=galM {ECO:0000313|EMBL:SPT69872.1};
GN ORFNames=NCTC13093_01263 {ECO:0000313|EMBL:SPT69872.1};
OS Anaerobiospirillum thomasii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Succinivibrionaceae; Anaerobiospirillum.
OX NCBI_TaxID=179995 {ECO:0000313|EMBL:SPT69872.1, ECO:0000313|Proteomes:UP000250086};
RN [1] {ECO:0000313|EMBL:SPT69872.1, ECO:0000313|Proteomes:UP000250086}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13093 {ECO:0000313|EMBL:SPT69872.1,
RC ECO:0000313|Proteomes:UP000250086};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; UAPV01000001; SPT69872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2X0WTL7; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000250086; Unassembled WGS sequence.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096};
KW Reference proteome {ECO:0000313|Proteomes:UP000250086}.
FT ACT_SITE 168
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 305
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 72..73
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 168..170
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 239
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 343 AA; 38728 MW; EAB82D9BE03CC8E8 CRC64;
MQDIYSQNPR LFRIKNASGM SVTVMDWGAT LISIKVPMTD GSMRETLLGL KNASDWKDQT
CYFNATIGRY ANRIANSNFT LGFKNYTLAS HDRHTLHGGI DGFDKRRFEV IDIKDNAITL
TLHSADGDQG FPGNYDLIVC YSLNDDNTLR VDYKGMCDAP CPSCITNHAY FNLNGYNSSI
LNHTLYLNSH AFLELDDSAI PTGKVLYTKD HSAFDFSKEK KIGLDFMNHA QMISARGYDH
PYLRDGEPCE SFARATSDDG KLTMEVFSDY PAFQFYTGNY IHAGNDIIAR DDNQVYANQS
GFCLEPEYYP DSVHLPDFAS VNPIVDQHNP LEKFIAYRFS ARS
//
