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Database: UniProt
Entry: A0A2X3EM11_KLUCR
LinkDB: A0A2X3EM11_KLUCR
Original site: A0A2X3EM11_KLUCR 
ID   A0A2X3EM11_KLUCR        Unreviewed;       136 AA.
AC   A0A2X3EM11;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Methyl viologen resistance protein C {ECO:0000313|EMBL:VFS83143.1};
DE   SubName: Full=Multidrug efflux SMR transporter {ECO:0000313|EMBL:HAT1571828.1};
GN   Name=emrE {ECO:0000313|EMBL:VFS83143.1};
GN   ORFNames=I8Y10_003213 {ECO:0000313|EMBL:HAT1571828.1}, NCTC12993_06321
GN   {ECO:0000313|EMBL:VFS83143.1};
OS   Kluyvera cryocrescens (Kluyvera citrophila).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Kluyvera.
OX   NCBI_TaxID=580 {ECO:0000313|EMBL:HAT1571828.1};
RN   [1] {ECO:0000313|EMBL:HAT1571828.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1571828.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [2] {ECO:0000313|EMBL:VFS83143.1, ECO:0000313|Proteomes:UP000401081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC12993 {ECO:0000313|EMBL:VFS83143.1,
RC   ECO:0000313|Proteomes:UP000401081};
RG   Pathogen Informatics;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HAT1571828.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1571828.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000256|ARBA:ARBA00038032, ECO:0000256|RuleBase:RU003942}.
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DR   EMBL; DACSDP010000013; HAT1571828.1; -; Genomic_DNA.
DR   EMBL; CAADJD010000025; VFS83143.1; -; Genomic_DNA.
DR   RefSeq; WP_061279910.1; NZ_VKGH01000003.1.
DR   AlphaFoldDB; A0A2X3EM11; -.
DR   STRING; 580.GCA_001266615_04412; -.
DR   OrthoDB; 9808638at2; -.
DR   Proteomes; UP000401081; Unassembled WGS sequence.
DR   Proteomes; UP000863970; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF1; MULTIDRUG TRANSPORTER EMRE; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000401081};
KW   Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   136 AA;  14614 MW;  A39E53F2987590DD CRC64;
     MSSKTKCWLW MLLVIVSETS ATSTLKMFDT SEGTTKTLLL ALIVVLYCVC YYSLSRAVKD
     IPVGLAYATW SGTGILVVST LGMAFYGQHP DTAAIIGMAI IASGIVIMNL FSKMGHEEAE
     ETPPTPVSTL DKNVAN
//
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