ID A0A2X3EM11_KLUCR Unreviewed; 136 AA.
AC A0A2X3EM11;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Methyl viologen resistance protein C {ECO:0000313|EMBL:VFS83143.1};
DE SubName: Full=Multidrug efflux SMR transporter {ECO:0000313|EMBL:HAT1571828.1};
GN Name=emrE {ECO:0000313|EMBL:VFS83143.1};
GN ORFNames=I8Y10_003213 {ECO:0000313|EMBL:HAT1571828.1}, NCTC12993_06321
GN {ECO:0000313|EMBL:VFS83143.1};
OS Kluyvera cryocrescens (Kluyvera citrophila).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Kluyvera.
OX NCBI_TaxID=580 {ECO:0000313|EMBL:HAT1571828.1};
RN [1] {ECO:0000313|EMBL:HAT1571828.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1571828.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [2] {ECO:0000313|EMBL:VFS83143.1, ECO:0000313|Proteomes:UP000401081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12993 {ECO:0000313|EMBL:VFS83143.1,
RC ECO:0000313|Proteomes:UP000401081};
RG Pathogen Informatics;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HAT1571828.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1571828.1};
RG NCBI Pathogen Detection Project;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC {ECO:0000256|ARBA:ARBA00038032, ECO:0000256|RuleBase:RU003942}.
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DR EMBL; DACSDP010000013; HAT1571828.1; -; Genomic_DNA.
DR EMBL; CAADJD010000025; VFS83143.1; -; Genomic_DNA.
DR RefSeq; WP_061279910.1; NZ_VKGH01000003.1.
DR AlphaFoldDB; A0A2X3EM11; -.
DR STRING; 580.GCA_001266615_04412; -.
DR OrthoDB; 9808638at2; -.
DR Proteomes; UP000401081; Unassembled WGS sequence.
DR Proteomes; UP000863970; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561:SF1; MULTIDRUG TRANSPORTER EMRE; 1.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000401081};
KW Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 136 AA; 14614 MW; A39E53F2987590DD CRC64;
MSSKTKCWLW MLLVIVSETS ATSTLKMFDT SEGTTKTLLL ALIVVLYCVC YYSLSRAVKD
IPVGLAYATW SGTGILVVST LGMAFYGQHP DTAAIIGMAI IASGIVIMNL FSKMGHEEAE
ETPPTPVSTL DKNVAN
//