ID A0A2X3EM70_KLUCR Unreviewed; 270 AA.
AC A0A2X3EM70;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Septum site-determining protein MinD {ECO:0000256|ARBA:ARBA00016887};
DE AltName: Full=Cell division inhibitor MinD {ECO:0000256|ARBA:ARBA00032845};
GN Name=minD {ECO:0000313|EMBL:HAT1572107.1};
GN Synonyms=minD_1 {ECO:0000313|EMBL:VFS73378.1};
GN ORFNames=I8Y10_003496 {ECO:0000313|EMBL:HAT1572107.1}, NCTC12993_04939
GN {ECO:0000313|EMBL:VFS73378.1};
OS Kluyvera cryocrescens (Kluyvera citrophila).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Kluyvera.
OX NCBI_TaxID=580 {ECO:0000313|EMBL:HAT1572107.1};
RN [1] {ECO:0000313|EMBL:HAT1572107.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1572107.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [2] {ECO:0000313|EMBL:VFS73378.1, ECO:0000313|Proteomes:UP000401081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12993 {ECO:0000313|EMBL:VFS73378.1,
RC ECO:0000313|Proteomes:UP000401081};
RG Pathogen Informatics;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HAT1572107.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=88CZ1 {ECO:0000313|EMBL:HAT1572107.1};
RG NCBI Pathogen Detection Project;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATPase required for the correct placement of the division
CC site. Cell division inhibitors MinC and MinD act in concert to form an
CC inhibitor capable of blocking formation of the polar Z ring septums.
CC Rapidly oscillates between the poles of the cell to destabilize FtsZ
CC filaments that have formed before they mature into polar Z rings.
CC {ECO:0000256|ARBA:ARBA00025436}.
CC -!- SUBUNIT: Interacts with MinC and FtsZ. {ECO:0000256|ARBA:ARBA00011626}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC -!- SIMILARITY: Belongs to the ParA family. MinD subfamily.
CC {ECO:0000256|ARBA:ARBA00010257}.
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DR EMBL; DACSDP010000015; HAT1572107.1; -; Genomic_DNA.
DR EMBL; CAADJD010000022; VFS73378.1; -; Genomic_DNA.
DR RefSeq; WP_061281099.1; NZ_VKGH01000008.1.
DR AlphaFoldDB; A0A2X3EM70; -.
DR STRING; 580.GCA_001266615_03931; -.
DR OrthoDB; 9773088at2; -.
DR Proteomes; UP000401081; Unassembled WGS sequence.
DR Proteomes; UP000863970; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd02036; MinD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR010223; MinD.
DR InterPro; IPR025501; MinD_FleN.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01968; minD_bact; 1.
DR PANTHER; PTHR43384:SF6; SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43384; SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR PIRSF; PIRSF003092; MinD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023210};
KW Cell division {ECO:0000256|ARBA:ARBA00023210};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000401081};
KW Septation {ECO:0000256|ARBA:ARBA00023210}.
FT DOMAIN 3..156
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 270 AA; 29703 MW; 9FC173B17D776F34 CRC64;
MARIIVVTSG KGGVGKTTSS AAIATGLAQK GKKTVVIDFD IGLRNLDLIM GCERRVVYDF
VNVIQGDATL NQALIKDKRT ENLYILPASQ TRDKDALTRE GVEKVLDELK KMEFDFVVCD
SPAGIETGAL MALYFADEAI ITTNPEVSSV RDSDRILGIL ASKSRRAENG EDPIKEHLLL
TRYNPGRVNK GDMLSMEDVL EILRIKLVGV IPEDQSVLRA SNQGEPVILD EVSDAGKAYA
DTVDRLLGEE RPFRFVEEEK KGFLKRLFGG
//
