ID A0A2X3Y2L3_9STRE Unreviewed; 456 AA.
AC A0A2X3Y2L3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=arlS_2 {ECO:0000313|EMBL:SQF41062.1};
GN ORFNames=NCTC12278_01658 {ECO:0000313|EMBL:SQF41062.1};
OS Streptococcus ferus.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1345 {ECO:0000313|EMBL:SQF41062.1, ECO:0000313|Proteomes:UP000249495};
RN [1] {ECO:0000313|EMBL:SQF41062.1, ECO:0000313|Proteomes:UP000249495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12278 {ECO:0000313|EMBL:SQF41062.1,
RC ECO:0000313|Proteomes:UP000249495};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LS483343; SQF41062.1; -; Genomic_DNA.
DR RefSeq; WP_018030667.1; NZ_LS483343.1.
DR AlphaFoldDB; A0A2X3Y2L3; -.
DR STRING; 1123303.GCA_000372425_01345; -.
DR KEGG; sfer:NCTC12278_01658; -.
DR OrthoDB; 9762826at2; -.
DR Proteomes; UP000249495; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF9; SENSOR HISTIDINE KINASE YRKQ; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249495};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SQF41062.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..221
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 243..453
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 206..233
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 456 AA; 52007 MW; F70EA0510A492ED4 CRC64;
MGIVRKNFLI VTSMIIATVL VLLAVIYYAM PIYYNQAKQV EIKNDYQAIV KQLDGKSTEK
LLSQIATYDK TNPNLLLTLM DDSGKILYPD ASDKEAADRR KTYLEKGQFD QIGSWSELIA
SSEGDAYIVQ AEYGFQSLSG ISQILLTFYP FILVFIVLLA SLVAYVYSRL SNKRIQTISE
TTRQMRALEE GLACQISGQD EIANLAQNIN QLYNHLLQSI AELKQENQRT VERERQQADF
LRITSHELKT PIASSLALVE GMLYNVGDFK DHDTYLRKCR DILQEQSVLV QSVLDATNLD
IGVKSHQETI DVKSLIEQNL DSYYILAETH SYQFSSTLTS YRVTANPAYL LKAIKNLLDN
AFRYTRAGGV IHLSLSEGRL ILENQAEQLL TDEELKHIFQ PFYRPDFSRD RKDGGTGMGL
YMVQQILDQH GFSYHFKRSG DKMRFILFLD RASIQD
//
