ID A0A2X4T4K1_SALER Unreviewed; 373 AA.
AC A0A2X4T4K1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=T-protein {ECO:0000256|PIRNR:PIRNR001499};
GN Name=tyrA {ECO:0000313|EMBL:SQI22146.1};
GN ORFNames=AHX45_18860 {ECO:0000313|EMBL:EDH0572132.1}, DSQ81_20035
GN {ECO:0000313|EMBL:ECI4937932.1}, F4V61_15455
GN {ECO:0000313|EMBL:KAA8662721.1}, NCTC7295_01318
GN {ECO:0000313|EMBL:SUG13727.1}, NCTC7307_01402
GN {ECO:0000313|EMBL:SQI22146.1};
OS Salmonella enterica subsp. arizonae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=59203 {ECO:0000313|EMBL:SQI22146.1, ECO:0000313|Proteomes:UP000248731};
RN [1] {ECO:0000313|Proteomes:UP000248731, ECO:0000313|Proteomes:UP000254124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC7295 {ECO:0000313|EMBL:SUG13727.1,
RC ECO:0000313|Proteomes:UP000254124}, and NCTC7307
RC {ECO:0000313|EMBL:SQI22146.1, ECO:0000313|Proteomes:UP000248731};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDH0572132.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FDA00001204 {ECO:0000313|EMBL:EDH0572132.1};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ECI4937932.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=475813 {ECO:0000313|EMBL:ECI4937932.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAA8662721.1, ECO:0000313|Proteomes:UP000322837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 6322T {ECO:0000313|EMBL:KAA8662721.1,
RC ECO:0000313|Proteomes:UP000322837};
RA Pineiro-Iglesias B., Tunovic T., Unosson C., Inganas E., Ohlen M.,
RA Cardew S., Jensie-Markopoulos S., Salva-Serra F., Jaen-Luchoro D.,
RA Karlsson R., Svensson-Stadler L., Chun J., Moore E.;
RT "Draft genome sequence of various Type strains from the CCUG.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC {ECO:0000256|PIRNR:PIRNR001499}.
CC -!- PATHWAY: Metabolic intermediate biosynthesis; prephenate biosynthesis;
CC prephenate from chorismate: step 1/1. {ECO:0000256|PIRNR:PIRNR001499}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR001499}.
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DR EMBL; AAIVIG010000038; ECI4937932.1; -; Genomic_DNA.
DR EMBL; AAMGFJ010000030; EDH0572132.1; -; Genomic_DNA.
DR EMBL; VXJW01000008; KAA8662721.1; -; Genomic_DNA.
DR EMBL; LS483466; SQI22146.1; -; Genomic_DNA.
DR EMBL; UGWZ01000001; SUG13727.1; -; Genomic_DNA.
DR RefSeq; WP_038394800.1; NZ_VXJW01000008.1.
DR AlphaFoldDB; A0A2X4T4K1; -.
DR UniPathway; UPA00120; UER00203.
DR UniPathway; UPA00122; UER00961.
DR Proteomes; UP000248731; Chromosome 1.
DR Proteomes; UP000254124; Unassembled WGS sequence.
DR Proteomes; UP000322837; Unassembled WGS sequence.
DR Proteomes; UP000839688; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0046417; P:chorismate metabolic process; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 1.20.59.10; Chorismate mutase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR008244; Chor_mut/prephenate_DH_T.
DR InterPro; IPR036263; Chorismate_II_sf.
DR InterPro; IPR036979; CM_dom_sf.
DR InterPro; IPR002701; CM_II_prokaryot.
DR InterPro; IPR011277; CM_T.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR NCBIfam; TIGR01799; CM_T; 1.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF01817; CM_2; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR PIRSF; PIRSF001499; Chor_mut_pdh_Tpr; 1.
DR SMART; SM00830; CM_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF48600; Chorismate mutase II; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51168; CHORISMATE_MUT_2; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001499};
KW Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001499};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR001499};
KW Isomerase {ECO:0000256|PIRNR:PIRNR001499, ECO:0000313|EMBL:EDH0572132.1};
KW NAD {ECO:0000256|PIRNR:PIRNR001499};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR001499};
KW Reference proteome {ECO:0000313|Proteomes:UP000248731};
KW Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR001499}.
FT DOMAIN 1..90
FT /note="Chorismate mutase"
FT /evidence="ECO:0000259|PROSITE:PS51168"
FT DOMAIN 99..361
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 373 AA; 41928 MW; B28DB83B2AD8951D CRC64;
MVAELTALRD QIDDVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE
AEAIGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL
SGYQVRILEQ QDWPRAGDIV ADAGMVIVSV PIHVTEQVIA KLPRLPSDCI LVDLASVKSG
PLQAMLAAHD GPVLGLHPMF GPDSGSLAKQ VVVWCDGRQP EAYQWFLEQI QVWGARLHRI
SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP
QLYADIIMSS KRNLALIKRY YKRFGDAIAL LEQGDKQAFI DSFRKVEHWF GDYARRFHNE
SRVLLRQAND SRQ
//
