ID A0A2X4TX99_SALER Unreviewed; 109 AA.
AC A0A2X4TX99;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Spermidine export protein MdtI {ECO:0000256|ARBA:ARBA00021114, ECO:0000256|HAMAP-Rule:MF_01597};
GN Name=mdtI {ECO:0000256|HAMAP-Rule:MF_01597,
GN ECO:0000313|EMBL:SQI24980.1};
GN ORFNames=AHX45_05160 {ECO:0000313|EMBL:EDH0569633.1}, DSQ81_20235
GN {ECO:0000313|EMBL:ECI4937969.1}, F4V61_01850
GN {ECO:0000313|EMBL:KAA8665713.1}, GBZ58_01780
GN {ECO:0000313|EMBL:HAB4459449.1}, NCTC7304_02888
GN {ECO:0000313|EMBL:SUG33412.1}, NCTC7307_03011
GN {ECO:0000313|EMBL:SQI24980.1}, NCTC8297_03149
GN {ECO:0000313|EMBL:SUG47870.1};
OS Salmonella enterica subsp. arizonae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=59203 {ECO:0000313|EMBL:SQI24980.1, ECO:0000313|Proteomes:UP000248731};
RN [1] {ECO:0000313|EMBL:HAB4459449.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB4459449.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [2] {ECO:0000313|Proteomes:UP000248731, ECO:0000313|Proteomes:UP000254741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC7304 {ECO:0000313|EMBL:SUG33412.1,
RC ECO:0000313|Proteomes:UP000254762}, NCTC7307
RC {ECO:0000313|EMBL:SQI24980.1, ECO:0000313|Proteomes:UP000248731}, and
RC NCTC8297 {ECO:0000313|EMBL:SUG47870.1,
RC ECO:0000313|Proteomes:UP000254741};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ECI4937969.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=475813 {ECO:0000313|EMBL:ECI4937969.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:EDH0569633.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FDA00001204 {ECO:0000313|EMBL:EDH0569633.1};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:KAA8665713.1, ECO:0000313|Proteomes:UP000322837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 6322T {ECO:0000313|EMBL:KAA8665713.1,
RC ECO:0000313|Proteomes:UP000322837};
RA Pineiro-Iglesias B., Tunovic T., Unosson C., Inganas E., Ohlen M.,
RA Cardew S., Jensie-Markopoulos S., Salva-Serra F., Jaen-Luchoro D.,
RA Karlsson R., Svensson-Stadler L., Chun J., Moore E.;
RT "Draft genome sequence of various Type strains from the CCUG.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:HAB4459449.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB4459449.1};
RG NCBI Pathogen Detection Project;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000256|HAMAP-
CC Rule:MF_01597}.
CC -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000256|ARBA:ARBA00011359,
CC ECO:0000256|HAMAP-Rule:MF_01597}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane {ECO:0000256|HAMAP-
CC Rule:MF_01597}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01597}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01597}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAIVIG010000039; ECI4937969.1; -; Genomic_DNA.
DR EMBL; AAMGFJ010000003; EDH0569633.1; -; Genomic_DNA.
DR EMBL; DAAGTC010000001; HAB4459449.1; -; Genomic_DNA.
DR EMBL; VXJW01000001; KAA8665713.1; -; Genomic_DNA.
DR EMBL; LS483466; SQI24980.1; -; Genomic_DNA.
DR EMBL; UGXD01000002; SUG33412.1; -; Genomic_DNA.
DR EMBL; UGXG01000002; SUG47870.1; -; Genomic_DNA.
DR RefSeq; WP_001183826.1; NZ_VXJW01000001.1.
DR AlphaFoldDB; A0A2X4TX99; -.
DR SMR; A0A2X4TX99; -.
DR OMA; VAAGWIM; -.
DR Proteomes; UP000248731; Chromosome 1.
DR Proteomes; UP000254741; Unassembled WGS sequence.
DR Proteomes; UP000254762; Unassembled WGS sequence.
DR Proteomes; UP000322837; Unassembled WGS sequence.
DR Proteomes; UP000839688; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.3730.20; -; 1.
DR HAMAP; MF_01597; MdtI; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023737; Spermidine_export_MdtI.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR PANTHER; PTHR30561:SF6; SPERMIDINE EXPORT PROTEIN MDTI; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01597};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01597};
KW Reference proteome {ECO:0000313|Proteomes:UP000248731};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01597};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01597};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01597}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
SQ SEQUENCE 109 AA; 11662 MW; CED50DF6488E3CCF CRC64;
MQQFEWVHGA WLALAIILEI AANVLLKFSD GFRRKCYGIL SLAAVLAAFS ALSQAVKGID
LSVAYALWGG FGIAATLAAG WVLFGQRLNP KGWVGVVLLL VGMIMIKLA
//