ID A0A2X4WMJ2_SALER Unreviewed; 592 AA.
AC A0A2X4WMJ2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=fixL {ECO:0000313|EMBL:SQI25094.1};
GN ORFNames=NCTC7307_03128 {ECO:0000313|EMBL:SQI25094.1};
OS Salmonella enterica subsp. arizonae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=59203 {ECO:0000313|EMBL:SQI25094.1, ECO:0000313|Proteomes:UP000248731};
RN [1] {ECO:0000313|EMBL:SQI25094.1, ECO:0000313|Proteomes:UP000248731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC7307 {ECO:0000313|EMBL:SQI25094.1,
RC ECO:0000313|Proteomes:UP000248731};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LS483466; SQI25094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2X4WMJ2; -.
DR Proteomes; UP000248731; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; NF040750; tetrathio_HK; 1.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF12974; Phosphonate-bd; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SQI25094.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248731};
KW Transferase {ECO:0000313|EMBL:SQI25094.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 305..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 364..581
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 592 AA; 65706 MW; 0A9DFAA6D0B08FEC CRC64;
MRGKTVRCLA ILAAVGLICH SVWAGSWNIG ILAMRGEAST RRHWQPLEMT LNQQIPGETF
HIQPLDLHQI QEAVNRRTVQ FVITNPAQFV RLNSHAPLRW LASLRSTRDG KAVGNVIGSV
ILTRRDSGIT TAHDLIGKTV GAIDAQAFGG YLLGYKALSD AGLRPERDFH FRFTGFPGDA
LVYMLREKAV QAAIVPVCLL ENMDQEGLID EKDFIALLSR PTTLPCLTST QLYPDWSFAA
LPAVSDALAD RVTRALFNAP AAAPFHWGAP ASTSQVEALL RDVRQHPQQH RLWLDVKSWL
IQHQLMVGGV TLAFLLLTLN YIWVMLLVRR RGKQLERNSV VLHQHERALE TARQMSVLGE
MTSGFAHELN QPLSAIRHYA QGCLIRLRVE DERHPLLSAL DHIDQQAQRG ADTLRNLRHW
VSQAQGNPVL TEEWKAIAIR EAIDHVWQLL RMAHQFPSVD LHTEVSAALR VTLPPVLLEQ
VLANVILNAA QAGATHLWII AERIENGVSI VLQDNAGGID NALLRQAFQP FMTTRKEGMG
LGLAICQRLV RYGRGDISIR NQTAPDGQAG TVVTIHFLQE NGGKDGDNTS IG
//
