ID A0A2Y9B9I2_9FIRM Unreviewed; 593 AA.
AC A0A2Y9B9I2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Adenine deaminase {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenase {ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase {ECO:0000256|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
GN Name=ade {ECO:0000256|HAMAP-Rule:MF_01518};
GN ORFNames=A8806_101539 {ECO:0000313|EMBL:PWJ32251.1},
GN SAMN05216536_101539 {ECO:0000313|EMBL:SSA54084.1};
OS Faecalicatena orotica.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Faecalicatena.
OX NCBI_TaxID=1544 {ECO:0000313|EMBL:SSA54084.1, ECO:0000313|Proteomes:UP000251306};
RN [1] {ECO:0000313|EMBL:SSA54084.1, ECO:0000313|Proteomes:UP000251306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-C242 {ECO:0000313|EMBL:SSA54084.1,
RC ECO:0000313|Proteomes:UP000251306};
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWJ32251.1, ECO:0000313|Proteomes:UP000245845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-C242 {ECO:0000313|EMBL:PWJ32251.1,
RC ECO:0000313|Proteomes:UP000245845};
RA Kelly W.;
RT "The Hungate 1000. A catalogue of reference genomes from the rumen
RT microbiome.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000479, ECO:0000256|HAMAP-
CC Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000256|ARBA:ARBA00006773,
CC ECO:0000256|HAMAP-Rule:MF_01518}.
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DR EMBL; QGDL01000001; PWJ32251.1; -; Genomic_DNA.
DR EMBL; UETE01000001; SSA54084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Y9B9I2; -.
DR OrthoDB; 9775607at2; -.
DR Proteomes; UP000245845; Unassembled WGS sequence.
DR Proteomes; UP000251306; Unassembled WGS sequence.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01518};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01518};
KW Reference proteome {ECO:0000313|Proteomes:UP000245845}.
FT DOMAIN 73..360
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT DOMAIN 416..580
FT /note="Adenine deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13382"
SQ SEQUENCE 593 AA; 64954 MW; 1A983B92236DEC13 CRC64;
MERTIANLKE MIRAGRGIIP ADTVVKGGNL VNVMTSEIYP ADVAIYKDMI AAVGDVSDYT
GPGTKIIDAE GKYLVPGLID GHIHSECSKL SITSFAKAVV PCGTTSMISG LDEYISVSGL
EGLKEVLAEV KQSPLKVFWG APYKTPYTIP ESTVSFNFTK EVHEEVQQWP ECFGVWETVR
EFLQEEDENT LGAIEQAFKN RLPVFGCAPM ARGNDLNGYL CGGVRLDHES YDHEEVVEKM
RKGMHMLIRE SSVTHFLAEN IRAVTEVNPY MARRVSFCTD DVTATDVLEK GHLDNVVRLA
IAAGVEPMTA IQMGTINSAE AYRIDHLVGS ISPGRIADIL LVDSPEEFHV ETVITNGQLV
AQNKKLTYDL KAPERSTVLK SELKCQKTTK ADFEYRVDMI NGTADVLAMD VQGPFVRKRR
DVVLNVEDGI ILPDPEQDVA LVSVLERFGR NGNRSLAFCS GWNLKRGAMA SSAAPDDNNL
IVMGVNPEDM SLAVNYLIEQ GGGQVVVADG EIIEFLPLPV GGIASDEEPE VIAAQEKKLN
KAAQDLGSTL PEPLMYMFFL PITAIPDYAI TDVGPVDYTN LTTFDPVIKL NEQ
//