ID A0A2Y9C9W8_9FIRM Unreviewed; 643 AA.
AC A0A2Y9C9W8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:SSA55336.1};
GN ORFNames=A8806_104215 {ECO:0000313|EMBL:PWJ30345.1},
GN SAMN05216536_104215 {ECO:0000313|EMBL:SSA55336.1};
OS Faecalicatena orotica.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Faecalicatena.
OX NCBI_TaxID=1544 {ECO:0000313|EMBL:SSA55336.1, ECO:0000313|Proteomes:UP000251306};
RN [1] {ECO:0000313|EMBL:SSA55336.1, ECO:0000313|Proteomes:UP000251306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-C242 {ECO:0000313|EMBL:SSA55336.1,
RC ECO:0000313|Proteomes:UP000251306};
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWJ30345.1, ECO:0000313|Proteomes:UP000245845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-C242 {ECO:0000313|EMBL:PWJ30345.1,
RC ECO:0000313|Proteomes:UP000245845};
RA Kelly W.;
RT "The Hungate 1000. A catalogue of reference genomes from the rumen
RT microbiome.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QGDL01000004; PWJ30345.1; -; Genomic_DNA.
DR EMBL; UETE01000004; SSA55336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Y9C9W8; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000245845; Unassembled WGS sequence.
DR Proteomes; UP000251306; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:SSA55336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245845};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 7..136
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..354
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 442..597
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 643 AA; 70820 MW; CB0D7E25084B70C3 CRC64;
MASTTRMTVA QALVKFLDNQ YVEFDGVETK FVEGFFTIFG HGIAVGLGEA LDTNPGQLNV
YQGRNEQGMC HVATAFAKQN NRRRIIPCAS SVGPGAANMV TACATATVNN IPLLVFPADT
FASRQPDPVL QQLEQSSSLA VTTNDAFKPV CKYWDRIVRP EQLMSAMINA MRVLTDPAET
GAVCIGLCQD VEGESYDYPD YFFKKRVHRI TRQAAAEEEI NDITEIIAEA KKPLIVVGGG
VKYSEAGETV EKFCEEFKIP FGESQAGKSA CRSSHPYCLG GIGVTGTLAA NDIAEDADVV
IAIGSRMSDF TTGSKRQYKN EDVKFVTINN SRFHAYKMDA VKAVGDAKAT VEALAEKLRA
KGYQSSYNGE IEAEKAKWDA EMERLANYRY QEENFEPMIQ ARDPRTIPEF VKLTDGRITQ
TAALCAIRRV IDEDATIITA GGSLPSCMQR IWTTDKRGGY HAEYGYSCMG YEVAAALGVK
IAEPDNEVYT VVGDSSFQML HSEIMTAMQQ RKKINILVFD NCGFGCINNL EMNHGIGSIA
TEFRYQEGNK PTGDLIPVDY AKIAEGYGLK SYTVRTIEEL EAALRDAKNQ DNAVLIDLKV
IPKTMTDGYN SWWNVGIATT SEKESVREAC EGVMEGRREA RAY
//
