ID A0A2Y9D7D5_TRIMA Unreviewed; 2118 AA.
AC A0A2Y9D7D5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Dysferlin isoform X2 {ECO:0000313|RefSeq:XP_004369268.1};
GN Name=LOC101355052 {ECO:0000313|RefSeq:XP_004369268.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004369268.1};
RN [1] {ECO:0000313|RefSeq:XP_004369268.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_004369268.1; XM_004369211.1.
DR GeneID; 101355052; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2084..2105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 230..352
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 391..527
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1153..1279
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1327..1455
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1599..1717
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1833..1981
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 172..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2033..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2118 AA; 240883 MW; 9F4A0CEEA49384C8 CRC64;
MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSSS FNAPLLDTKK QPTGASLVLQ
VSYTPLPGAA PLFPPPAPLE PSPTMPDLDV VAGGGQSRAE TWSLLSDSTM DTRYSGKKWQ
APMDTGEEED TEDQGLTGDE AEPFPDQSSA QGPGAPTTPR KPPSHPPPYH PGSKRKRSAP
RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP VVKVTTAGQT KRTRIHKGNS PLFNETLFFN
VFDSPAELFD EPIFITVVDS RSLRTDALIG EFRMDVGTIY REPRHAYLRK WLLLSNPDDF
SVGARGYLKA SLCVLGPGDE APLERKDPSE DKEDIEGNLL RPTGVALRGA HFCLKVFRAE
DLPQMDDAVM DNVKQIFGFD SNKKNLVDPF VEVSFAGKML CSKILEKTAN PQWNQSITLP
AMFPSMCEKM RVRVIDWDRL THNDIVATTY LSMSRISAPG GEIEVDDHMG FLPTFGPCYV
NLYGSPREFT GFPDPYAELN TGKGEGVAYR GRLLLSLETK LVEHSELKVE DLPADDILRV
EKYLRRRKYS LFAAFYSASM LQDVDDAIQF EVSIGNYGNK FDTTCLPLAS TTQYSRAVFD
GCHYYYLPWG NVKPVVVLSS YWEDISHRIE TQNRLLRIAD RLEAGLEQVH LALKAQCSTE
DVDSLVAQLM DDLIAHCSQP LGDIRQMPSA THLDQYLYQL RIRHLNQITE AALALKLGHS
ELPAALEQAE DWLLRLRALA DEPQNSLPDI VIWMLQGDKR VAYQRVPAHE VLFSRRGASY
CGKSCGKLQT IFLKYPMESV PGARMPVQIR VKLWFGLSVD EKEFNQFAEG KLSVFAETYE
NQTKLALVGN WGTTGLTYPK FSDVTGKIKL PKDSFRPSTG WAWAGDWFVC PEKTLLHDAD
AGHLSFVEEV FENQTRLPGG QWIYMSDNYT DVNGEKVLPK DDIECPLGWK WEDEEWSTDL
NRAVDEQGWE YSITIPPDRK PRHWVPAEKM YYTHRRRRWV RLRRRDLSQM EELKRHRQAE
AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR WRRRMEPLEK TGPAAVFALE GALGGVVDDK
SEDSISVSTL SFGVNRPTIS CIFDYGNRYH LRCYMYQARD LPAMDKDSFS DPYAIVSFLH
QSQKTVVAKN TLNPTWDQTL IFYEIEIFGE PVSIAEQPPS IVVELYDHDT YGADEFLGRC
ICQPSLERMP RLAWFPLTRG SQAAGELLAS FELIQREKPA IHHIPGFEVQ DTSGILEESE
DTDLPYPPPQ REANIYVVPQ NIKPVLQRTA IEILAWGLRN MKSYQLASVS SPSLIVECGG
QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR EELYCPPIVV KVIDNRQFGR RPVVGQCTIR
SLESFLCDPY SVESPSPQGG PDDVSLVSPG EEVLIDIDDK EPLIPLQLAD GLLGSALINL
ASSPSSPHEE EFIDWWSKFF ASTGEREKCG SYLEKDFDTL KVYDTPLENV EAFEGLSDFC
NTFQLYRGKT QEEMEDPSVT GEFKGLFKIY PLPEDPAIPM PPRQFHQLAA QGPQECLVRI
YIVRAFGLQP KDPNGKCDPY VRISIGKKSV SDQDNYIPCT LEPVFGKMFE LTCTVPLEKD
LKIALYDYDL LSKDEKIGET VIDLENRLLS KFGAHCGLPQ TYSVSGPNQW RDQLRPSQLL
HLFCQQHRLK APVYRTDRVV FQDKEYTIEE IEAGKVPNPH LGPVEERLAL HVLQQQGLVP
EHVESRPLYS PLQPDIEQGK LQMWIDLFPK ALGRPGPPFN ITPRRAKRFF LRCIIWNTKD
VILDDLSITG EKMSDIYVKG WMVGFEEHKQ KTDVHYRSLG GEGNFNWRFI FPFDYLPAEQ
VCTVSKKDAF WRLDKTESKI PARVVFQIWD NDKFSFDDFL GSLQLDLNHM PKPAKTAEKC
SLDQLDDTFH PERFVSLLEQ KTMKGWWPCV AQAGEKQMLA GKLEMTLEIV AESEHEERPA
GQGRDEPNMN PKLEDPRRPD TSFLWFTSPY KTMKFILWRR FRCAIILFII LFILLLFLGI
FVYAFPNYAA MKLVKPFS
//
