ID A0A2Y9D816_TRIMA Unreviewed; 140 AA.
AC A0A2Y9D816;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Calcitonin {ECO:0000256|ARBA:ARBA00015874};
GN Name=LOC101356272 {ECO:0000313|RefSeq:XP_004369729.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004369729.1};
RN [1] {ECO:0000313|RefSeq:XP_004369729.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
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DR RefSeq; XP_004369729.1; XM_004369672.1.
DR AlphaFoldDB; A0A2Y9D816; -.
DR STRING; 127582.A0A2Y9D816; -.
DR GeneID; 101356272; -.
DR KEGG; tmu:101356272; -.
DR InParanoid; A0A2Y9D816; -.
DR OrthoDB; 4002581at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR021118; Calcitonin.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505:SF16; CALCITONIN; 1.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00270; CALCITONINA.
DR SMART; SM00113; CALCITONIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..140
FT /note="Calcitonin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015845924"
FT DOMAIN 82..119
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT REGION 113..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 140 AA; 15500 MW; A61BCF53775DA43A CRC64;
MGFWKSSPFL ALSFLVLYQV GSLQAAPFRS AIESSPDLTA LSEEEARLLL AALVKDFVQI
KASELEQEQE TEDSSLDSLR TKRYSSLSTC MLGTYLQDLN KFHTFPQTAI GVGAPGKKRD
MASDLKRNHH SPFGMPQDAN
//
