ID A0A2Y9D8G9_TRIMA Unreviewed; 1676 AA.
AC A0A2Y9D8G9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protocadherin-15 isoform X14 {ECO:0000313|RefSeq:XP_004369947.1};
GN Name=LOC101349340 {ECO:0000313|RefSeq:XP_004369947.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004369947.1};
RN [1] {ECO:0000313|RefSeq:XP_004369947.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004369947.1; XM_004369890.1.
DR GeneID; 101349340; -.
DR OrthoDB; 5353563at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 9.
DR Gene3D; 2.60.40.3430; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; EC_dom_sf.
DR PANTHER; PTHR24026:SF93; CADHERIN-99C; 1.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 11.
DR SUPFAM; SSF49313; Cadherin-like; 10.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 11.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1375..1397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..147
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 148..265
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 278..395
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 396..509
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 510..616
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 617..717
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 719..819
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 820..926
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 927..1035
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1037..1144
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1145..1259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1425..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 185817 MW; D2C5CF6C81B343C8 CRC64;
MLRQFYLWKC LASGIILGPL FTISLGQYDD DCKLARGGPP ATIVAIDEES RNGTIIVDNM
MIKGTAGGPN PTIELSLKDN VDYWVLLDPV KQMLFLNSTG RVLDRDPPMN IHSLVVQVQC
INKKVGTVIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTVFTGF SGDNGATDID
DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNVMLRKRL NYEDKTRYFV IIQANDRAQN
LNERRTTTTT LTVDILDGDD LGPMFLPCVL VPNTRDCRPI TYQAAIPELR SPEELNPIIV
TPPIEAIDQD QNIQPPSDRP GILYSILVGT PEDYPRFFHM HPKTAELSLL EPVNRDFHQK
FDLVIKAEQD NGHPLPAFAS LHIEILDENN QSPYFTMPSY QGYILESAPV GSTISDSLNL
TTPLRIVVLD KDIEDTKDPE VHLFLNDYTS VFTVTQTGIT RYLTLLQPVD REEQQTYTFS
ITAFDGVQES KPVIINIRVM DANDNTPTFP EISYDVYVYT DMSPGDSVLQ LTAIDADEGS
NGEITYEILV GAQGDFIINK TTGLITIAPE VDLIVGRTYA LTVQAADNAP PAERRHSICT
VYIEVLPPNN QSPPRFPQLM YSLEISEAMR IGAVLLNLQA TDREGDPITY AIENGDPQRV
FNLSETTGLL SLGKALDRES TDRYILIVTA SDGRPDGTST ATVNVVVTDV NDNAPVFDPY
LPRNLSVVEE EANAFVGQVR ATDPDAGING QVYYSLGNFN NLFRITSNGS IYTAVKLNRE
VRDYYELVVV ATDGAVHPRH STLTLAIKVL DIDDNSPVFT NSTYTVIVEE NLPAGTTFLR
IEAKDVDLGA NVSYRIRGPE VKHFFALHPF TGELSLLRSL DYEAFPGQEA TITFLVEAFD
IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGLPA
SRVRYRVDDV QFPYPASIFD VEEDSGLVIT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA
TVKILVLHPG EIPHFTQEEY RPPPVSELAT KGTVVGVISA AAINQSIVYS IVSGNEEGAF
GINNITGVIY VKAPLDYETK TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENDH
PPVFSKKFYI GGVSEDARMF TSVLKVQATD VDTGNYSAMA YRLIIPPIKE GKEGFVVETY
TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSSKADVLV SVVNQLDMQV IVSNVPPTLV
EKKIEDLTEI LDHYVQEQIP GAKVVVESIG ARRHGDAFSL EDYTKCDLTV YAIDPQTNRA
IDRNELFKFL DGKLLDINKD FQPYYGEGGR ILEIRTPEAV TSIKKRGESL GYTEGALLAL
AFIIILCCIP AILVVLVSYR QFKVRQAECT KTARIQSALP AAKPAAPAPA PVAAPPPPPP
PPGAHLYEEL GDSTMHKYEM PQYGSRRRLL PPTGQEEYGE VVGEAEEEYE EEEWARKRMI
KLVADREYES SSTGEDSAPE CQRNRLHNPN IHSSINGNIY IAQNGSVVRT RRACLTDNLK
VTSPVRMGRH SKKLDKLAVM HEENIPLNTL SKGPFSTEKL NTRPSLVTFA PCPVGTDSTA
VKLLGNRLKS AVEQESMADS KNIKQPLEFL SDHTQSDDEE LWMGPWNNLH IPMTKL
//
