ID A0A2Y9D8K4_TRIMA Unreviewed; 540 AA.
AC A0A2Y9D8K4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Probable G-protein coupled receptor 75 {ECO:0000313|RefSeq:XP_004369521.1};
GN Name=LOC101341877 {ECO:0000313|RefSeq:XP_004369521.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004369521.1};
RN [1] {ECO:0000313|RefSeq:XP_004369521.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004369521.1; XM_004369464.3.
DR AlphaFoldDB; A0A2Y9D8K4; -.
DR STRING; 127582.A0A2Y9D8K4; -.
DR GeneID; 101341877; -.
DR KEGG; tmu:101341877; -.
DR InParanoid; A0A2Y9D8K4; -.
DR OrthoDB; 2939859at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15007; 7tmA_GPR75; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1.
DR PANTHER; PTHR24228:SF59; G-PROTEIN COUPLED RECEPTOR 75-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_004369521.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..376
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 540 AA; 59654 MW; CF6F07878827B7E8 CRC64;
MNSTDPLQDA PNATWLHVPH SQGENSTSVQ EDLQGLIHTA TLVTCTLLLL IIFCLGSYGN
FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM FTFVLFFSSA SSIPDAFCFT
FHLTSSGFII MSLKTVAVIA LHRLRMVLGK QPNRTASFPC TLLLTLLLWA TSFTLATLAT
LKTSKSQLCL PMSSPPAGGG QAVLSLYVVD FAFCVAVVSV SYIMIAQTLR NNAQLRKCPP
VITVDASRPQ PFMGVPVKGG REPVQCTMPA LYRNQNYNKL QHVQTHGYTK SPNQLLSPAA
SRLQLVSAVN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLANNG SFILYQLELF
GFILIFFKSG LNPFIYSRNS AGLRRKVFWC LQYIGLGFFC CKQKTRLRAM GKGNLEVNRN
KSSHHETNSA YMLSPKPQKK FVDQACGPSH SRESMISPKM SAGHQHYGQS SSTPINTRIE
PYYSIYNSSP SQEESIAHNL QPVNAFGFAH SYIAMHYHTT NDLMQEYDST SAKQIPVPSV
//
