ID A0A2Y9D9X8_TRIMA Unreviewed; 867 AA.
AC A0A2Y9D9X8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 2 isoform X2 {ECO:0000313|RefSeq:XP_004370234.1};
GN Name=LOC101341626 {ECO:0000313|RefSeq:XP_004370234.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004370234.1};
RN [1] {ECO:0000313|RefSeq:XP_004370234.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004370234.1; XM_004370177.1.
DR AlphaFoldDB; A0A2Y9D9X8; -.
DR GeneID; 101341626; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR020969; Ankyrin-G_BS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF16642; KCNQ2_u3; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01461; KCNQ2CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 91..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..320
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 464..648
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 400..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..717
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 95369 MW; 53E79386B46D16F9 CRC64;
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEASKR GSILSKPRAP
GAGKPPKRNA FYRKLQNFLY NVLERPRGWA FIYHAYVFLL VFSCLVLSVF STIKEYEKSS
EGALYILEIV TIVVFGVEYF VRIWAAGCCC RYRGWRGRLK FARKPFCVID IMVLIASIAV
LAAGSQGNVF ATSALRSLRF LQILRMIRMD RRGGTWKLLG SVVYAHSKEL VTAWYIGFLC
LILASFLVYL AEKGENDHFD TYADALWWGL ITLTTIGYGD KYPQTWNGRL LAATFTLIGV
SFFALPAGIL GSGFALKVQE QHRQKHFEKR RNPAAGLIQS AWRFYATNLS RTDLHSTWQY
YERTVTVPMY SSQTQTYGAS RLIPPLNQLE LLRNLKSKSG LTFRKEPQPE PSPRSGAECR
ESLCGCCPGH SSQKVSLKDR VFSSPRGVAT KGKGSPQAQT VRRSPSADQS LEDSPGKVPK
SWSFGDRSRA RQAFRIKGAA SRQNSEEASL PGEDPVEDNK SCNCEFVTED LTPGLKVSIR
AVCVMRFLVS KRKFKESLRP YDVMDVIEQY SAGHLDMLSR IKNLQSRVDQ IVGRGPAITD
KDRTKGPAEA ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV NIYMQRMGIP PAETEAYFGA
KEPEPAPPYH SPEDSREHLG KNGCIIKVVR SASSMGQKNF AAPPAAPPTP CPPSTSWQPQ
GCPRQGPGSS PVGDPGALVR IPPPPTHERS LSAYSGGHRA SSEFLRHEDV ARPPEGGLRD
SDTSISIPSV DHEELERSFS GFSISQSKEQ LDALGYAAVA PCVKVRPYIA EGESDTDSDL
CTPCGPPPRS ATSEGPFGDL GWAGSRK
//
