ID A0A2Y9DBR9_TRIMA Unreviewed; 1606 AA.
AC A0A2Y9DBR9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Roundabout homolog 1 isoform X3 {ECO:0000313|RefSeq:XP_004371397.1};
GN Name=LOC101353981 {ECO:0000313|RefSeq:XP_004371397.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004371397.1};
RN [1] {ECO:0000313|RefSeq:XP_004371397.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004371397.1; XM_004371340.1.
DR GeneID; 101353981; -.
DR OrthoDB; 5396194at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05724; IgI_2_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF9; ROUNDABOUT GUIDANCE RECEPTOR 1; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 29..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..218
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 315..410
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 419..505
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 527..621
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 640..737
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 742..838
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1038..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1606 AA; 175957 MW; 6598ED260696BCA3 CRC64;
MIAEPARFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI
EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH
NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT
IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA
EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VMASDMGSYT CVAENMVGKA
EASATLTVQV GSEPPHFVVK PRDQVVAMGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY
QPPQSSSRFS VSQTGDLTIT NVQRPDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV
IRQGPVNQTV AVDGTLVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE TGVLQIRYAK
LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT
VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETFAVKGLKP NAIYLFLVRA
ANAYGISDPS QISDPVKTQD VPPTSQGVDH KQVQRELGNV VLHLHNPTIL SSSSIEVHWT
VDQQSQYIQG YKILYRPSGA NRGESEWLVF EVRTPTKNSV VIPELKKGVN YEIKARPFFN
EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV TWQPPPEDTQ NGMVQEYKVW
CLGNETRYHI NKSVDGSTFS VVIPSLVPGI RYSVEVAAST GAGPGVKSEP QFIQLDSHGN
PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLASTYAGIR
KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSINCC TAGNGNSDSN
LTTYSRPADC IANYNNQLDN KQTNLMLPES SVYGDVDLSN KINEMKTFNS PNLKDGRFVN
PSGQPTPYAT TQLIQSNLSN NMNNGSGDSS EKHWKPSGQQ KQEVAPIQYN IMEQNKLNKD
YRANDTIPPT IPYNQSYDQN TGGSYNSSDR GSSTSGSQGH KKGARTPKVP KQGGMNWADL
LPPPPVHPPP HSNSEEYSIS VDESYDQEMP CPVPPARMYL QQDELEEEED ERGPTPPVRG
AASSPAAVSY SHQSTATLTP SPQEELQPML QDCPEEIGHV QHQPDRRRQP VSPPPPPRPI
SPPHTYGYIS GPLVSDMDTD APEEEEDEAD MEVAKMQTRR LLLRGLEQTP ASSVGDLESS
VTGSMINGWG SASEEDNISS GRSSVSSSDG SFFTDADFAQ AVAAAAEYAG LKVARRQMQD
AAGRRHFHPS QCPRPTSPVS TDSNMSAAVM QKARPAKKQK HQPGHLRREA YTDDLPPPPV
PPPAIKSPTV QSKAQLEVRP VMVPKLPPIE ARTDRSSDRK GGSYKGREVL DGRQVADMRT
NPGDLREAQE QQNDGKGRGN KAAKRDLPPA KTHLIQEDIL PYCRPTFPTS NNPRDPSSSS
SMSSRGSGGR QREQANVGRR NIAEMQVLGG YERGEDNNEE LEETES
//
