ID A0A2Y9DBT8_TRIMA Unreviewed; 584 AA.
AC A0A2Y9DBT8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Zinc finger protein 599 {ECO:0000313|RefSeq:XP_004371656.1};
GN Name=LOC101341972 {ECO:0000313|RefSeq:XP_004371656.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004371656.1};
RN [1] {ECO:0000313|RefSeq:XP_004371656.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004371656.1; XM_004371599.2.
DR AlphaFoldDB; A0A2Y9DBT8; -.
DR GeneID; 101341972; -.
DR KEGG; tmu:101341972; -.
DR InParanoid; A0A2Y9DBT8; -.
DR OrthoDB; 5250644at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24381:SF20; ZINC FINGER PROTEIN 599; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 195..222
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 223..250
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 251..278
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 279..306
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 307..334
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 335..362
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 363..390
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 391..418
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 419..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..502
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 531..558
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 559..584
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 73..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 66686 MW; 2C541C02ACBC9DAF CRC64;
MAAPALALVS FEDVAVTFTG EEWQYLDLAQ RILYQEVMLE TCGLLVSLGH PVPKPELIFL
LEHRQELWTM KRGLSQSISP GEKAKPKTTE PTASLPTSDE TSFQEQVTQG ASKDFRLEQA
RDQEGPSEKQ EGNMRPGTYP HKETCPRKLS PDLGTDDSLC IRMLQERVTP EDALHEQDSH
GPGKDSMTEA GKNPYNCKEC GKGFSKNWTL VRHQKIHAGV KPYECNECGK ACHYMADFIR
HMRFHTGEKP YKCIECGKAF KRRSHLTEHQ RVHTGEKPYE CKECGKAFTH RSSFIQHNMT
HSGEKPFLCK ECGKAFHYSS SFAQHMRIHT GKKLYECSEC GKTFTHRSTF IQHNMIHMGE
KPFLCKECGK AFCLSSSFTQ HMRIHTGEKP YGCSECGKAF THRSTFIRHN RTHTGEKPFE
CKECGKAFCD SSSLIQHTRI HTGEKPYKCS VCGKAFTHHS VFIRHNRTHS GEKSLECKEC
GKAFYYSSSF TRHMRIHSGE RPYVCNECGK TFTQPANFVR HSRIHTGEKP FECKKCEKAF
CDNFALTQHM RSHTGEKPFE CSECGKAFSH SSSFIHHQKI HARV
//
