ID A0A2Y9DC77_TRIMA Unreviewed; 691 AA.
AC A0A2Y9DC77;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=LOC101357864 {ECO:0000313|RefSeq:XP_004371876.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004371876.1};
RN [1] {ECO:0000313|RefSeq:XP_004371876.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) +
CC glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:57305;
CC Evidence={ECO:0000256|ARBA:ARBA00033997};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A9 subfamily. {ECO:0000256|ARBA:ARBA00010056}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004371876.1; XM_004371819.1.
DR AlphaFoldDB; A0A2Y9DC77; -.
DR STRING; 127582.A0A2Y9DC77; -.
DR GeneID; 101357864; -.
DR KEGG; tmu:101357864; -.
DR InParanoid; A0A2Y9DC77; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR CDD; cd11498; SLC6sbd_GlyT1; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR003028; Na/ntran_symport_glycine_GLY1.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF263; SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01204; GLY1TRNSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurotransmitter transport {ECO:0000256|ARBA:ARBA00022775};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 76459 MW; 907B35F5BF87F782 CRC64;
MSCGDTRALS TRPGMASAGG PMAPASPEQP CPGLLSVSLR RSVLKVWHGV SSSGLLKVMA
QHPLAMAPNG AVPSEATKRD QNLKRGNWGN QIEFVLTSVG YAVGLGNVWR FPYLCYRNGG
GAFMFPYFIM LIFCGIPLFF MELSFGQFAS QGCLGVWRIS PMFKGVGYGM MVVSTYIGIY
YNVVICIAFY YFFSSMTHVL PWAYCNNPWN TPDCAGVLDA TNLTNGSRPA SLPSNLSHLL
NHTFQRTSPS EEYWRLYVLK LSDDIGNLGE VRLPLLGCLG VSWVVVFLCL IRGVKSSGKV
VYFTATFPYV VLTILFVRGV TLEGAFAGIM YYLTPQWDKI LEAKVWGDAA SQIFYSLGCA
WGGLITMASY NKFHNNCYRD SVIISITNCA TSVYAGFVIF SILGFMANHL GVDVSRVADH
GPGLAFVAYP EALTLLPISP LWSLLFFFML ILLGLGTQFC LLETLVTAIV DEVGNEWILQ
KKTYVTLGVA VAGFLLGIPL TSQAGIYWLL LMDNYAASFS LVVISCIMCV SIMYIYGHRN
YFQDIQMMLG FTPPVFFQIC WRFVSPAIIF FILIFTVIQY QPITYNHYQY PGWAVVIGFL
MALSSVICIP LYALFQLCRT DGDTLLQRLK NATKPSRDWG PALLEHRTGR YAPTIAPSPE
DGLEVQPLHP DKAQIPIMGS NGSSHLQDSR I
//
