ID A0A2Y9DCR6_TRIMA Unreviewed; 437 AA.
AC A0A2Y9DCR6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Sorting nexin-30 {ECO:0000256|ARBA:ARBA00015234};
GN Name=LOC101340528 {ECO:0000313|RefSeq:XP_004372213.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004372213.1};
RN [1] {ECO:0000313|RefSeq:XP_004372213.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_004372213.1; XM_004372156.2.
DR AlphaFoldDB; A0A2Y9DCR6; -.
DR STRING; 127582.A0A2Y9DCR6; -.
DR GeneID; 101340528; -.
DR KEGG; tmu:101340528; -.
DR InParanoid; A0A2Y9DCR6; -.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07667; BAR_SNX30; 1.
DR CDD; cd06860; PX_SNX7_30_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028649; SNX30_BAR.
DR PANTHER; PTHR45949:SF1; SORTING NEXIN-30; 1.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 89..210
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 49709 MW; 832F1EDBC944266B CRC64;
MSGGPPKALP STGPHSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMTRSFG DKDLILPNGG
TPAGTSSPAS SSSLLNRLQL DDDIDGETRD LFVTVDDPKK HVCTMETYIT YRITTKSTRV
EFDLPEYSVR RRYQDFDWLR NKLEESQPTH LIPPLPEKFV VKGVVDRFSE EFVETRRKAL
DKFLKRITDH PVLSFNEHFN VFLTAKDLNA YKKQGMALLT RVGESVKHVT GGYKLRSRPL
EFAAIGEYLD TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG
VSACIGNCST ALEELTDDMT EDFLPVLREY ILYSDSMKSV LKKRDQVQAE YETKLEAVAL
RKEDRPKVPA DVEKCQDRME CFNADLKADM ERWQNNKRQD FRQLLMGMAD KNIQYYEKCL
TAWESIIPLL QEKQEAK
//
