ID A0A2Y9DD85_TRIMA Unreviewed; 284 AA.
AC A0A2Y9DD85;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Four and a half LIM domains protein 5 {ECO:0000256|ARBA:ARBA00021696};
GN Name=LOC101344201 {ECO:0000313|RefSeq:XP_004372463.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004372463.1};
RN [1] {ECO:0000313|RefSeq:XP_004372463.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC Stimulates CREM transcriptional activity in a phosphorylation-
CC independent manner. {ECO:0000256|ARBA:ARBA00025444}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004372463.1; XM_004372406.1.
DR AlphaFoldDB; A0A2Y9DD85; -.
DR STRING; 127582.A0A2Y9DD85; -.
DR GeneID; 101344201; -.
DR KEGG; tmu:101344201; -.
DR InParanoid; A0A2Y9DD85; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09343; LIM1_FHL; 1.
DR CDD; cd09428; LIM2_FHL5; 1.
DR CDD; cd09347; LIM4_FHL; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR InterPro; IPR042947; FHL5_LIM2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; FOUR AND A HALF LIM DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24205:SF7; FOUR AND A HALF LIM DOMAINS PROTEIN 5; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 39..100
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 161..220
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 221..283
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 284 AA; 32697 MW; BAE86104A4D4F878 CRC64;
MTATQFDCQY CTASLLGKKY VLKDDHLYCV SCYDRVFSNY CEECKEPIES DSKDLCYKGR
HWHGGCFNCA KCNHSLVEKP FAAKDERLLC TECYSNQCSS KCFHCKKTIM PGSRKMEFKG
SYWHETCLVC EHCRQPIGTK PVISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFHDQ
PWHKECFLCS GCRKELYEEE LMSRDDYPFC LDCYNHLYAK KCAACSKPIT GLRGVKFICF
QDRQWHSDCF NCGRCSISLV GEGFLTQNED IFCRKCGSGV DTDI
//
