ID   A0A2Y9DDN8_TRIMA        Unreviewed;      1338 AA.
AC   A0A2Y9DDN8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Astrotactin-2 isoform X1 {ECO:0000313|RefSeq:XP_004372179.1};
GN   Name=LOC101353986 {ECO:0000313|RefSeq:XP_004372179.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004372179.1};
RN   [1] {ECO:0000313|RefSeq:XP_004372179.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004372179.1; XM_004372122.1.
DR   STRING; 127582.A0A2Y9DDN8; -.
DR   GeneID; 101353986; -.
DR   KEGG; tmu:101353986; -.
DR   InParanoid; A0A2Y9DDN8; -.
DR   OrthoDB; 4157619at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR040685; Annexin-like.
DR   InterPro; IPR045574; ASTN1_2_Fn3.
DR   InterPro; IPR045575; ASTN_1_2_N.
DR   InterPro; IPR040510; ASTN_2_hairpin.
DR   InterPro; IPR026995; Astrotactin.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR16592; -; 1.
DR   PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR   Pfam; PF18411; Annexin_2; 1.
DR   Pfam; PF19743; ASTN1_2_fn3; 1.
DR   Pfam; PF19441; ASTN_1_2_N; 1.
DR   Pfam; PF18577; ASTN_2_hairpin; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..47
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           48..1338
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016067835"
FT   TRANSMEM        203..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          850..1034
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          368..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..316
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1338 AA;  148252 MW;  052733BB47E4FAC1 CRC64;
     MAAAGARRSP GPSSGLRGRT RLGFHPAPPP PLLLLFLLLL LPPPLLAGAT AAASREPDSP
     CRLKTVTVST LPALQESDIG WSGARAGAGT GAGAAAAAAA AASPGSAGSA GTAAESRLLL
     FVRNELPGRI AVQDDLDNTE LPFFTLEMSG TAADISLVHW RQQWLENGTL YFHVSMSSSG
     QLAQATTPTL QEPSEIVEEQ MHILHISVMG GLIALLLLLL VFTVALYAQR RWQKRRHIPQ
     KSASTEATHE IHYIPSVLLG PQARESFRSS RLQAHNSVIG VPIRETPILD DYDYEEDEDP
     PRRANHVSHE DEFGSQVTHT LDSLGRPGEE KVDFEKKAAA EATQETVESL MQKFKESFRA
     NTPIEIGQLQ PAPRSVSAGK RRRRSKSRGG ISFGRTKGTS GSEADDETQL TFYTEQYRSR
     HRSKGLLKSP VNKTALTLIA VSSCILAMVC GSQMSCPLTV KVTLHVPEHF IADGSSFVVS
     EGSYLDISDW LNPAKLSLYY QINATSPWVR DLCGQRTTDA CEQLCDPETG ECSCHEGFAP
     DPVHRHLCVR SDWGQSEGPW PYTTLERGYD LVTGEQAPEK ILRSTFSLGQ GLWLPVSKSF
     VVPPVELSIN PLASCKTDVL VTEDPADVRE EALLSTYFET INDLLSSFGP VRDCSRNNGG
     CTRNFKCVSD RQVDSSGCVC PEELRPMKDG SGCYDHSKGI DCSDGFNGGC EQLCLQQTLP
     LPYDATSSTI FMFCGCVEEY KLAPDGKSCL MLSDVCEGPK CLKPDSRFND TLFGEMLHGY
     NNRTQHVNQG QVFQMTFREN NFIKDFPQLA DGLLVIPLPV EEQCRGVLSE PLPDLQLLTG
     DIRYDEAMGY PMVQQWRVRS NLYRVKLSTI TLSAEFTNVL KILTKESSRE ELLSFIQHYG
     SHYITEALYG SELTCIIHFP SKKVQQQLWL QYQKETTELG SKKELKSMPF ITYLSGLLTA
     QMLSDDQLIS GVEIRCEEKG RCPSTCHLCR RPGKEQLSPT PVLLEINHVV PLYTLIQDNG
     TKETFKSALM SSYWCSGKGD VIDDWCRCDL SAFDANGLPN CSPLLQPVLR LSPTVEPSST
     VVSLEWVDVQ PAIGTKVSDY ILQHKKVDEY TDTDLYTGEF LSFADDLLSG LGTSCVAAGR
     SHGEIPEVSI YSVIFKCLEP DGLYKFTLYA VDTRGRHSEL STVTLRTACP LVDDNKAEEI
     ADKIYNLYNG YTSGKEQQTA YNTLMEVSAS MLFRVQHHYN SHYEKFGDFV WRSEDELGPR
     KAHLILRRLE RVSSHCSSLL RSAYIQSRVD TVPYLFCRSE EVRPAGMVWY SILKDTKITC
     EEKMVSMARN TYGESKGR
//