ID A0A2Y9DEA9_TRIMA Unreviewed; 863 AA.
AC A0A2Y9DEA9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
GN Name=LOC101341145 {ECO:0000313|RefSeq:XP_004372812.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004372812.1};
RN [1] {ECO:0000313|RefSeq:XP_004372812.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004372812.1; XM_004372755.2.
DR AlphaFoldDB; A0A2Y9DEA9; -.
DR STRING; 127582.A0A2Y9DEA9; -.
DR GeneID; 101341145; -.
DR KEGG; tmu:101341145; -.
DR InParanoid; A0A2Y9DEA9; -.
DR OrthoDB; 2876738at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|RefSeq:XP_004372812.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_004372812.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|RefSeq:XP_004372812.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..559
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 640..846
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 97335 MW; 59C3C34C09E65FD7 CRC64;
MASLYQRFTG KINTSRSFPA PPEASRLLGG QGAEEDGGGA GARTLRPQVP AAPQEHGGGG
TGGRPRFQYQ ARNDCEDEDE LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPAED
NSLSQKKKVT VEDLFSEDFK IHDPEAKWIS DKELIYREQK GNVILRNVET NISTVLIEGK
KIESLRAVRY EISPDKEYAL FSYNVESIYQ HSYTGYYVLS KIPHGDPQSL DPPEVSNAKL
QYAGWGPKGQ QLIFIFENNI YYCAQVGKQV IRVVSTGKEG VIYNGLSDWL YEEEILKTHI
AHWWSPDGTR LAYATINDSR VPLMELATYT GSVYPTVKPY HYPKAGCENP SISLHVIGLS
GPTHDLEMVP PDDPRMRDYY ITVVKWATST KVAVNWLNRA QNVSILTLCD ATTGVCTKKH
EDESEAWLHR QNEEPVFSKD GRKFFFVRAI PQGGRGKFYH ITVSSSQPNS SNDNIQSITS
GDWDVTKILA YDEKRNKIYF LSTEDLPRRR QLYSANTVGN FNRQCLSCDL IENCTYFSAS
FSHNMDFFLL KCEGPGVPTV TVHNTTDKKK IFDLETNEHV QKAINDRQMP KVEYRKIEID
DYNLPMQILK PATFTDTAHY PLLLVVDGAP GSQSVAEKFE VNWETVMVSS HGAVVVKCDG
RGSGFQGTNL LHEVRKKLGS VEEKDQMEAV RKMLKEQYID KTRVAVFGKD YGGYLSTYIL
PAKGENQGQI FTCGSAVSPI TDFKLYASAF SERYLGLHGL DNRAYEMTKV AHRLSALEGQ
QFLIIHATAD EKIHFQHTAE LITQLIKGKA NYSLQIYPDE SHYFHSAFLK QHLYRSIISF
FVECFRIQDK LPTVTTKEDE EED
//
