ID A0A2Y9DEF8_TRIMA Unreviewed; 1184 AA.
AC A0A2Y9DEF8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Myelin transcription factor 1-like protein isoform X2 {ECO:0000313|RefSeq:XP_004373147.1};
GN Name=LOC101356294 {ECO:0000313|RefSeq:XP_004373147.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004373147.1};
RN [1] {ECO:0000313|RefSeq:XP_004373147.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR RefSeq; XP_004373147.1; XM_004373090.1.
DR AlphaFoldDB; A0A2Y9DEF8; -.
DR GeneID; 101356294; -.
DR KEGG; tmu:101356294; -.
DR OrthoDB; 3091993at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 6.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF11; MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 6.
DR SUPFAM; SSF103637; CCHHC domain; 6.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 620..870
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 56..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1056..1125
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 90..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 133267 MW; 9EBB7EFD17451DF0 CRC64;
MEVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR SVYGCPLAKK
RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD EKEEDEEEEY SEDNEEQGDE
EEEDEEVDRE EEEEIEEEDD DDDEDGDDVE DEEEEEEEEE EEEEEEEENE DHQMNCHNTR
IMQDTEKDDN NNDEYDNYDE LVAKSLLNLG KIAEDAAYRA RTESEMNSNT SNSLEDDSDK
NENLGRKSEL SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN INDRNYVDSM SQQDNRNMNY
VMLGKPMNNG LLEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQER NQQQNMNIRQ
HVRQEDDFPG RTPDRNYSDM MNLMRLEEQL SPRSRTFSSC AKEDGCHERD DDTTSVNSDR
SEEVFDMTKG NLTLLEKAIA LETERAKAMR EKMAMEAGRR DNMRSYEEQS PRQLSGEERK
PKSSDSHVKK PYYDPSRTEK KESKCPTPGC DGTGHVTGLY PHHRSLSGCP HKDRVPPEIL
AMHENVLKCP TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY DNHTYGKRAI
APKVQTRDIS PKGYDAKRYC KNSSPTSSTT SSYAPSSSSN MSCGGGSSAS STCSKSSFDY
THDMEAAHMA ATAILNLSTR CREMPQNLST KPQDLCAARN PDMEVDENGT LDLSMNKQRP
RDGCCPILTP LEPMSPQQQA VMNNRCFQLN EGDCWDLPVD YTKMKPRRID EDDPKEITPE
ELDPFQEALE ERRYPGEVTI PSPKPKYPQC KESKKDLITL SGCPLADKSI RSMLATSSQE
LKCPTPGCDG SGHITGNYAS HRSLSGCPRA KKSGIRIAQS KEDKEDQEPI RCPVPGCDGQ
GHITGKYASH RSASGCPLAA KRQKDGYLNG SQFSWKSVKT EGMSCPTPGC DGSGHVSGSF
LTHRSLSGCP RATSAMKKAK LSGEQMLTIK QRASNGIEND EEIKQLDEEI KELNESNSQM
EADMIKLRTQ ITTMESNLKT IEEENKVIEQ QNESLLHELA NLSQSLIHSL ANIQLPHMDP
INEQNFDAYV TTLTDMYTNQ DRYQSPENKA LLENIKQAVR GIQV
//
