ID A0A2Y9DF61_TRIMA Unreviewed; 566 AA.
AC A0A2Y9DF61;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Lipase maturation factor {ECO:0000256|RuleBase:RU361229};
GN Name=LOC101343074 {ECO:0000313|RefSeq:XP_004373428.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004373428.1};
RN [1] {ECO:0000313|RefSeq:XP_004373428.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the maturation of specific proteins in the
CC endoplasmic reticulum. {ECO:0000256|RuleBase:RU361229}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU361229}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361229}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC {ECO:0000256|ARBA:ARBA00005512, ECO:0000256|RuleBase:RU361229}.
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DR RefSeq; XP_004373428.1; XM_004373371.1.
DR AlphaFoldDB; A0A2Y9DF61; -.
DR STRING; 127582.A0A2Y9DF61; -.
DR GeneID; 101343074; -.
DR KEGG; tmu:101343074; -.
DR InParanoid; A0A2Y9DF61; -.
DR OrthoDB; 180704at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR InterPro; IPR009613; LMF.
DR PANTHER; PTHR14463; LIPASE MATURATION FACTOR; 1.
DR PANTHER; PTHR14463:SF10; LIPASE MATURATION FACTOR 1; 1.
DR Pfam; PF06762; LMF1; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361229};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361229};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361229};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361229}.
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 126..155
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 175..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 203..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 64536 MW; B35DF2BC91470B71 CRC64;
MRFYGPAMAA PAESLRKRRR GDAGSGSPPE PACEPVGYPT RLRAGSFWLT RIVLLRALAF
VYFVAFLVAF HQNKQLIGDQ GLLPSRLYLK SVQQHFKGRI GWDALSYAPT VLWFLDWSRM
DTNLDFLALA GLGISSFVLV AGCANMVLMA ALWVLYMSLV NVGQIWYAFG WESQLLETGF
LGIFLCPLWT LSRLPRRTPT SRIVVWGFRW LILRIMLGAG LIKIRGDRCW WDLTCMDYHY
ETQPVPNPAA YYLHRSPWWI HRAETLGNHI VELLVPFFLL LGRRMCILHG ILQVLFQVVL
IISGNLSFLN WLTIVPSLAC FDDNALGFLF PSRPGGLRDC VLHLQEEEAR GAGPVQTRGC
VVRRTVHLAL AALIGYLSIP VVLNLLSSQQ VMNVSFNPLR IVNTYGAFGS ITKERTEIIL
QGTASPNASA PSAVWEDYEF RCKPGDPRRR PCLISPYHHR LDWLMWFAAF QTYEQHEWII
HLAGKLLAND AWALSLLAHN PFTGRAPPRW VRAEHYRYKF SLPGGRHAAQ GEWWVRRRIG
PYFPPLSLQG LRDYFEAREW PHPEPA
//
