ID   A0A2Y9DFF3_TRIMA        Unreviewed;       641 AA.
AC   A0A2Y9DFF3;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Amiloride-sensitive sodium channel subunit beta {ECO:0000256|ARBA:ARBA00039757};
DE   AltName: Full=Beta-NaCH {ECO:0000256|ARBA:ARBA00043222};
DE   AltName: Full=Epithelial Na(+) channel subunit beta {ECO:0000256|ARBA:ARBA00042602};
DE   AltName: Full=Nonvoltage-gated sodium channel 1 subunit beta {ECO:0000256|ARBA:ARBA00042734};
DE   AltName: Full=SCNEB {ECO:0000256|ARBA:ARBA00041932};
GN   Name=LOC101354417 {ECO:0000313|RefSeq:XP_004373390.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004373390.1};
RN   [1] {ECO:0000313|RefSeq:XP_004373390.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1B subfamily. {ECO:0000256|ARBA:ARBA00038224}.
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DR   RefSeq; XP_004373390.1; XM_004373333.1.
DR   AlphaFoldDB; A0A2Y9DFF3; -.
DR   STRING; 127582.A0A2Y9DFF3; -.
DR   GeneID; 101354417; -.
DR   KEGG; tmu:101354417; -.
DR   InParanoid; A0A2Y9DFF3; -.
DR   OrthoDB; 5344287at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF18; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Ion channel {ECO:0000313|RefSeq:XP_004373390.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022480};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Taste {ECO:0000256|ARBA:ARBA00022480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   641 AA;  72449 MW;  51446011EA341B91 CRC64;
     MHVKKYLLKC LHRLQKGPGY TYKELLVWYC NNTNTHGPKR IICEGPKKKA MWFVLTLLFT
     SLVCWQWGIF IKTYLSCKVS VSLSMDFKNM DFPAVTICNA SPFQYSKVKH LLKDLDELME
     AVLERILAPE SSHANATRAL NFTIWNHTPL VLIDERNPHH PVVLDLFGDN YNGSASSSPA
     PGRICNAQGC KVAIRLCSSN GTVCTFQKFT SATQAVMEWY VLQATNIFSQ VPRKELMKMG
     YPAEQLILAC LFGAEPCSYR NFTSIFYPDY GNCYIFNWGM TDKTLPSANP GAEFGLKLIL
     DIGQEDYVPF LTSTAGARLM LHKQKSYPFV KDEGIYAMAG METSIGVLVD KLERKGKPYS
     QCTMNGSDVP IRNLYSDYNT TYSIQACLRS CFQELMIQNC SCGHYLYPLP HGEKYCNNQD
     FPDWAYCYLA LRISVKQREA CISKCRESCN DTTYTMTISM AEWPSDSSED WIFHILSQER
     DQSDNITISR KGVVKLNIYF QEFNDRTIQE SPANNIVWLL SNLGGQFGFW MGGSVLCLIE
     FGEILIDFVW ITIIKLVAFS KSLRQRQAQA RYAGPPPTVA ELVEAHTNFG FQPDMVDHSP
     DTGAYADGQT LPVPGTPPPN YDSLRLQPLD VIESDSEGDV I
//