ID A0A2Y9DFI5_TRIMA Unreviewed; 221 AA.
AC A0A2Y9DFI5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Acylpyruvase FAHD1, mitochondrial {ECO:0000256|ARBA:ARBA00041179};
DE EC=3.7.1.5 {ECO:0000256|ARBA:ARBA00039040};
DE EC=4.1.1.112 {ECO:0000256|ARBA:ARBA00012947};
DE AltName: Full=Fumarylacetoacetate hydrolase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042340};
DE AltName: Full=Oxaloacetate decarboxylase {ECO:0000256|ARBA:ARBA00032305};
GN Name=LOC101355175 {ECO:0000313|RefSeq:XP_004373217.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004373217.1};
RN [1] {ECO:0000313|RefSeq:XP_004373217.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:16526; EC=4.1.1.112;
CC Evidence={ECO:0000256|ARBA:ARBA00000288};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate;
CC Xref=Rhea:RHEA:19009, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:57278; EC=3.7.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00036322};
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
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DR RefSeq; XP_004373217.1; XM_004373160.3.
DR AlphaFoldDB; A0A2Y9DFI5; -.
DR STRING; 127582.A0A2Y9DFI5; -.
DR GeneID; 101355175; -.
DR KEGG; tmu:101355175; -.
DR InParanoid; A0A2Y9DFI5; -.
DR OrthoDB; 9433at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR PANTHER; PTHR11820; ACYLPYRUVASE; 1.
DR PANTHER; PTHR11820:SF7; ACYLPYRUVASE FAHD1, MITOCHONDRIAL; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SUPFAM; SSF56529; FAH; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 16..216
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 221 AA; 24478 MW; 075823CE512D0250 CRC64;
MAAPRQLSRF WEWGKNIVCV GRNYAEHARE MRSAVLSEPV LFLKPSSAYA PEGSPILMPA
YSRDLQHELE LGVVIGQRAR AVPQAAAMDY VAGYALCLDM TARDVQNECK KQGLPWTLAK
GFTASCPVSA FVPKEKIPDP HKLRLWLKVN GELRQEGETS SMIFSIPYII SYVSKIITLE
EGDIILTGTP KGVGPVKEND EIQAGIDGVV SMRFKVERPE C
//
