ID A0A2Y9DGR6_TRIMA Unreviewed; 430 AA.
AC A0A2Y9DGR6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=LOC101345443 {ECO:0000313|RefSeq:XP_004374338.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374338.1};
RN [1] {ECO:0000313|RefSeq:XP_004374338.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_004374338.1; XM_004374281.1.
DR AlphaFoldDB; A0A2Y9DGR6; -.
DR GeneID; 101345443; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 68..376
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 72..220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 267..347
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 430 AA; 49375 MW; 904B189DF5584781 CRC64;
MERRRITSAA RRSYVSSETV VGGLGPSRRL GSGTRLSLAR IPPPLPARVD FSLAGALNAG
FKETRASERA EMMELNDRFA SYIEKVRFLE QQNKTLAAEL NQLRAKEPTK LADVYQAELR
ELRLRLDQLT ATSARLEAER DNLAQDLDTL RQKFQDETSL RLEAENNLAG YRQEADEATL
ARLDLERKIE SLEEEIRFLR KIHEEEMQEL QEQLARQQVH VELDMAKPDL TAALREIRTQ
YEAVATSNMH EAEEWYRSKF ADLTDAAARN TELLRQAKHE ANDYRRQLQA LTCDLESLRG
TNESLERQMR ELEERHAREA ASYQEALARL EEEGQSLKDE MARHLQEYQE LLNVKLALDI
EIATYRKLLE GEENRITIPV QTFSNLQIRG DKSTREGEGH KVTRHLKNLT IQVIPIEVHP
IVNGALPALG
//
