ID A0A2Y9DH08_TRIMA Unreviewed; 1756 AA.
AC A0A2Y9DH08;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=LOC101357545 {ECO:0000313|RefSeq:XP_004374205.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374205.1};
RN [1] {ECO:0000313|RefSeq:XP_004374205.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_004374205.1; XM_004374148.1.
DR GeneID; 101357545; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR GO; GO:0031581; P:hemidesmosome assembly; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012013; Integrin_bsu-4.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF42; INTEGRIN BETA-4; 1.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002513; Integrin_B4; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00237; Calx_beta; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1756
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016160751"
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1130..1219
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1223..1322
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1462..1557
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1575..1671
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1667..1688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1756 AA; 195225 MW; 7BCCB0D2E8A6FB55 CRC64;
MGGPRPSPWT RVLLVALLSI SFPGHMANHC KKAQVKSCTE CIRVGKDCAY CTDQMFKERR
CNTQAELLAA GCRQESVVFM ESSFEITEET HIDTTLKRSQ VSPQGLRVWL RPGEERHFEF
EVFEPLESPV DLYILMDFSN SMSDDLANLK QMGHNLAQVL RQLTSDYTIG FGKFVDKVSV
PQTDMRPEKL KEPWPNSDPP FSFKNVISLT QDVEEFRSKL QGERISGNLD APEGGFDAIL
QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDEECHL DASGTYTQYK
MQDYPSVPTL VRLLGKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVDLLQ
EAFEAIRSNL DIRALDSPRG LRTEITSKMF PKTETGSFHI RRGEVGTYNV QLRAIEEVNG
MHVCQLPAED HRGNIHLKPS FSDGLRMDVG IICDVCTCEL QKEVRSPLCS FNGDFTCGHC
VCSEGWSGKT CNCSTGSLSD KQPCLREGED EPCSGRGECQ CGRCVCYGEG RYEGQFCEYD
NLQCPRTSGF LCNDRGHCTM GQCVCEPGWT GPGCDCPLSN ATCTDSNGGI CNGRGHCECG
RCHCNQQSLY TDTTCEINYS AIRLGLCEDM RSCVQCQAWG TGEKKGRPCE ECSFKVKMVD
ELKKAEDVVE YCSFRDEDDD CTYSYTVEGD STPGPNTTVL VHNRKDCPPG SFWWLIPLLI
FLLLLLALLL LLCWKYCACC KACLALLPCC NRGHMVGFKE DHYMLRENLM ASDHLDTPLL
RSGNLKGRDT VRWKITNNVQ RPGFTTRSVS SNPTELVPYG LSLRLARLCT ENLLKPDTRE
CEQLRQEVEE NLNEVYRQVT GDHKLQQTTF RQQPNAGKKQ DHTIVDTVLM APRSAKQALL
SLTEKHVGQG AFHELKVAPG YYTLTADQDA RGMVEFQDGV ELVDVRVPLF IRPEDDDEKQ
LLVEAIDVPS GTATLGRRLV NITIIKEQAS GVVSFEKPEY VVSHREQVAR IPIVRRIIDS
GKSQVSYHTQ DNTAHGNRDY IPVEGELLFH TGETWKELQV KLLELQEMDS LLRGRQTRRF
LIHLSNPKFG ARLGQPHSAT VIIGDGDEVD RSVTNWTLSS LPLVHSDPAA PQNPNAKAAG
PRKIHFNWLP PPGKPTGYKV KYWIQGDSEA EAQVLDSKVP SVELTNLYPY CNYEMKVCAY
GPQGESPYSS LVTCRTHQEV PSEPGRLAFN VVSSTVTQLS WAEPAETNGE ITAYEVCYGP
VNEDNLPIGP MKKVLVDSPK RRMLLIENLR ESQPYRYTVK ARNGAGWGPE REAFINLATQ
PKRPMSIPII PDIPIVDAQS GEDYNSFLMY SDDVLRSPSG SQRPSVSDDT EHLVNGRMDF
TFPGSANSLH RMTVANAAYG THLSPHLPHR VLSTSSTLTR DYNSLTRTEH SHSQSATLPR
DYSTLTSLSS HDSHMAAGVP NTPTRLVFSA LGPTSLKVSW QEPQCERALQ GYSVEYQLLN
GDELHRLDIP NPSQTSVVVE DLLPNHSYVF RVRAQSQEGW GPEREGVITI ESQVHPQSPL
CPLPGSAFTL STPSAPGPLV FTALSPDSLQ LSWERPRRPL GDILGYLVTC EIAHGGGPAT
TFLVDGDSPE SRLTVPGLSE NVPYKFKVQA KTTQGFGPER EGIITIESQD GGPFPQPGSH
PGLFQPSLPG EYSSVTTTTT HTNTTEPFLA DGLTLGSQHL EMGGSLTQHV TQEFVSRTLT
TSGTLSTQVD HQFYHT
//
